Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES)
Background: The cardiometabolic index (CMI) is a reliable marker used to assess the degree of obesity and lipid metabolism disorders in individuals. Emerging evidence indicates that disorders of lipid metabolism and sarcopenia share a common pathophysiologic basis. However, few studies have investig...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | Journal of Clinical & Translational Endocrinology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221462372500033X |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849228356365582336 |
|---|---|
| author | Yi Shen Jiayu Zhang Xiuyue Qiu |
| author_facet | Yi Shen Jiayu Zhang Xiuyue Qiu |
| author_sort | Yi Shen |
| collection | DOAJ |
| description | Background: The cardiometabolic index (CMI) is a reliable marker used to assess the degree of obesity and lipid metabolism disorders in individuals. Emerging evidence indicates that disorders of lipid metabolism and sarcopenia share a common pathophysiologic basis. However, few studies have investigated the association between CMI and sarcopenia. Therefore, this study aimed to find the possible correlation between CMI and sarcopenia. Methods: This study used cross-sectional research methods to investigate data on CMI, sarcopenia, and other covariates among participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. We explored the relationship between CMI and sarcopenia through multivariate linear and logistic regression, and we performed sensitivity and subgroup analyses. Also, receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) were utilized to evaluate the performance of CMI in identifying sarcopenia. Results: Of the 4,808 adults aged 20 to 59 included in this study, 428 (8.90 %) were identified as having sarcopenia. A significant nonlinear association between CMI and sarcopenia was demonstrated in a generalized additive model (GAM). After inclusion of all covariates, CMI showed a significant association with the prevalence of sarcopenia (OR = 1.173(1.086–1.267), P < 0.001). CMI got an AUC of 0.69 in identifying sarcopenia. Finally, subgroup analyses showed that the association between CMI and sarcopenia was particularly pronounced in individuals who differed in marital status, poverty-to-income ratio, alcohol consumption, patients without diabetes, and patients with hypertension (P < 0.05). Conclusion: This study demonstrated that an elevated CMI was associated with an increased prevalence of sarcopenia. The finding suggests that CMI could serve as a potential marker for sarcopenia, highlighting the need for further research to explore the relationship between dyslipidemia and sarcopenia. |
| format | Article |
| id | doaj-art-3c5eaa132e1b4c64ba4e2f9a0e8fe4ef |
| institution | Kabale University |
| issn | 2214-6237 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Clinical & Translational Endocrinology |
| spelling | doaj-art-3c5eaa132e1b4c64ba4e2f9a0e8fe4ef2025-08-23T04:48:30ZengElsevierJournal of Clinical & Translational Endocrinology2214-62372025-09-014110041510.1016/j.jcte.2025.100415Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES)Yi Shen0Jiayu Zhang1Xiuyue Qiu2School of Nursing, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310051, ChinaSchool of Nursing, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310051, ChinaCorresponding author at: 548 Binwen Road, Binjiang District, Hangzhou City, Zhejiang Province, China.; School of Nursing, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310051, ChinaBackground: The cardiometabolic index (CMI) is a reliable marker used to assess the degree of obesity and lipid metabolism disorders in individuals. Emerging evidence indicates that disorders of lipid metabolism and sarcopenia share a common pathophysiologic basis. However, few studies have investigated the association between CMI and sarcopenia. Therefore, this study aimed to find the possible correlation between CMI and sarcopenia. Methods: This study used cross-sectional research methods to investigate data on CMI, sarcopenia, and other covariates among participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. We explored the relationship between CMI and sarcopenia through multivariate linear and logistic regression, and we performed sensitivity and subgroup analyses. Also, receiver operating characteristic (ROC) curve analysis and area under the curve (AUC) were utilized to evaluate the performance of CMI in identifying sarcopenia. Results: Of the 4,808 adults aged 20 to 59 included in this study, 428 (8.90 %) were identified as having sarcopenia. A significant nonlinear association between CMI and sarcopenia was demonstrated in a generalized additive model (GAM). After inclusion of all covariates, CMI showed a significant association with the prevalence of sarcopenia (OR = 1.173(1.086–1.267), P < 0.001). CMI got an AUC of 0.69 in identifying sarcopenia. Finally, subgroup analyses showed that the association between CMI and sarcopenia was particularly pronounced in individuals who differed in marital status, poverty-to-income ratio, alcohol consumption, patients without diabetes, and patients with hypertension (P < 0.05). Conclusion: This study demonstrated that an elevated CMI was associated with an increased prevalence of sarcopenia. The finding suggests that CMI could serve as a potential marker for sarcopenia, highlighting the need for further research to explore the relationship between dyslipidemia and sarcopenia.http://www.sciencedirect.com/science/article/pii/S221462372500033XCardiometabolic indexSarcopeniaDyslipidemiaNHANESCross-sectional study |
| spellingShingle | Yi Shen Jiayu Zhang Xiuyue Qiu Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES) Journal of Clinical & Translational Endocrinology Cardiometabolic index Sarcopenia Dyslipidemia NHANES Cross-sectional study |
| title | Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES) |
| title_full | Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES) |
| title_fullStr | Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES) |
| title_full_unstemmed | Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES) |
| title_short | Association between cardiometabolic index and sarcopenia: 2011–2018 National Health and Nutrition Examination survey (NHANES) |
| title_sort | association between cardiometabolic index and sarcopenia 2011 2018 national health and nutrition examination survey nhanes |
| topic | Cardiometabolic index Sarcopenia Dyslipidemia NHANES Cross-sectional study |
| url | http://www.sciencedirect.com/science/article/pii/S221462372500033X |
| work_keys_str_mv | AT yishen associationbetweencardiometabolicindexandsarcopenia20112018nationalhealthandnutritionexaminationsurveynhanes AT jiayuzhang associationbetweencardiometabolicindexandsarcopenia20112018nationalhealthandnutritionexaminationsurveynhanes AT xiuyueqiu associationbetweencardiometabolicindexandsarcopenia20112018nationalhealthandnutritionexaminationsurveynhanes |