Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models
Abstract While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and...
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202411768 |
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| author | Yang Mou Yan Zhang Yuxian Zheng Guang He Zhi‐Xiang Xu Xiao Xiao Yong Ping |
| author_facet | Yang Mou Yan Zhang Yuxian Zheng Guang He Zhi‐Xiang Xu Xiao Xiao Yong Ping |
| author_sort | Yang Mou |
| collection | DOAJ |
| description | Abstract While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and humans. However, the neural circuits underlying vibration‐induced sleep (VIS) and its potential therapeutic benefits on neuropathological processes in disease models remain unclear. Here, it is shown that intermittent vibration, such as cycles of 30 s on followed by 30 s off, is more effective in inducing sleep compared to continuous vibration. A clear evidence is further provided that allatostatin A (AstA)‐GABA signaling mediates short‐term intermittent vibration‐induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABAA receptors. The existence of iVIS in mice is corroborated, implicating the GABAergic system in this process. Finally, intermittent vibration not only enhances sleep but also reduces amyloid‐β (Aβ) deposition and reverses memory defects in Alzheimer's disease models. In conclusion, the study defines a central neural circuit involved in mediating short‐term iVIS and the potential implications of vibration in treating sleep‐related brain disorders. |
| format | Article |
| id | doaj-art-3c42af8efa304a3584e17729f5dc7d91 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-3c42af8efa304a3584e17729f5dc7d912025-02-04T13:14:54ZengWileyAdvanced Science2198-38442025-02-01125n/an/a10.1002/advs.202411768Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease ModelsYang Mou0Yan Zhang1Yuxian Zheng2Guang He3Zhi‐Xiang Xu4Xiao Xiao5Yong Ping6Bio‐X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 ChinaBio‐X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 ChinaBio‐X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 ChinaBio‐X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 ChinaState Key Laboratory of Medical Neurobiology MOE Frontiers Center for Brain Science, and Institutes of Brain Science Fudan University Shanghai 200032 ChinaKey Laboratory of Computational Neuroscience and Brain‐Inspired Intelligence Ministry of Education Behavioural and Cognitive Neuroscience Center Institute of Science and Technology for Brain‐Inspired Intelligence MOE Frontiers Center for Brain Science Fudan University Shanghai 200433 ChinaBio‐X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education) Shanghai Jiao Tong University Shanghai 200240 ChinaAbstract While animals across species typically experience suppressed consciousness and an increased arousal threshold during sleep, the responsiveness to specific sensory inputs persists. Previous studies have demonstrated that rhythmic and continuous vibration can enhance sleep in both animals and humans. However, the neural circuits underlying vibration‐induced sleep (VIS) and its potential therapeutic benefits on neuropathological processes in disease models remain unclear. Here, it is shown that intermittent vibration, such as cycles of 30 s on followed by 30 s off, is more effective in inducing sleep compared to continuous vibration. A clear evidence is further provided that allatostatin A (AstA)‐GABA signaling mediates short‐term intermittent vibration‐induced sleep (iVIS) by inhibiting octopaminergic arousal neurons through activating GABAA receptors. The existence of iVIS in mice is corroborated, implicating the GABAergic system in this process. Finally, intermittent vibration not only enhances sleep but also reduces amyloid‐β (Aβ) deposition and reverses memory defects in Alzheimer's disease models. In conclusion, the study defines a central neural circuit involved in mediating short‐term iVIS and the potential implications of vibration in treating sleep‐related brain disorders.https://doi.org/10.1002/advs.202411768allatostatin Aalzheimer's diseaseGABA, sleepvibration |
| spellingShingle | Yang Mou Yan Zhang Yuxian Zheng Guang He Zhi‐Xiang Xu Xiao Xiao Yong Ping Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models Advanced Science allatostatin A alzheimer's disease GABA, sleep vibration |
| title | Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models |
| title_full | Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models |
| title_fullStr | Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models |
| title_full_unstemmed | Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models |
| title_short | Intermittent Vibration Induces Sleep via an Allatostatin A‐GABA Signaling Pathway and Provides Broad Benefits in Alzheimer's Disease Models |
| title_sort | intermittent vibration induces sleep via an allatostatin a gaba signaling pathway and provides broad benefits in alzheimer s disease models |
| topic | allatostatin A alzheimer's disease GABA, sleep vibration |
| url | https://doi.org/10.1002/advs.202411768 |
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