Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies
Background: Budd–Chiari syndrome (BCS) requires a constellation of clinical, imaging, and histological findings for diagnosis. Liver biopsy serves as a tool for confirming the diagnosis, even though the histological characteristics are not pathognomonic. Aims: To determine which constellation of mor...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_325_22 |
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| author | Pallavi Prasad Anurag Singh Alka Singh Prabhaker Mishra Narendra Krishnani |
| author_facet | Pallavi Prasad Anurag Singh Alka Singh Prabhaker Mishra Narendra Krishnani |
| author_sort | Pallavi Prasad |
| collection | DOAJ |
| description | Background:
Budd–Chiari syndrome (BCS) requires a constellation of clinical, imaging, and histological findings for diagnosis. Liver biopsy serves as a tool for confirming the diagnosis, even though the histological characteristics are not pathognomonic.
Aims:
To determine which constellation of morphologic findings could aid in establishing a diagnosis of BCS in clinically suspected cases.
Materials and Methods:
A 5-year retrospective observational study was conducted. The clinical, laboratory, and histological findings of liver biopsies in patients with a clinical diagnosis of BCS were studied. Cases were segregated into two groups on the basis of the number of histological features present. A scoring system was then devised to assess the efficacy of the histological findings in diagnosing BCS.
Statistical Analysis Used:
The continuous variables were compared using the Mann–Whitney U-test, and categorical variables were compared using the Fisher-exact test.
Results:
The common histopathological findings were the presence of red blood cells in the space of disse (100%), peri-portal fibrosis (97.1%), sinusoidal dilation (97.1%), portal inflammation (67.6%), centrilobular necrosis (61.8%) and pericellular/sinusoidal fibrosis (61.8%). Comparison between the two groups showed that centrilobular necrosis, lobular inflammation, portal inflammation, central vein fibrosis, and pericellular/sinusoidal fibrosis were significant parameters. No correlation was found between the clinical and laboratory parameters and the two groups.
Conclusions:
The liver biopsy features in BCS are often nonspecific, and no single feature in isolation is characteristic. A constellation of features (centrilobular necrosis, lobular inflammation, portal inflammation, central vein fibrosis, and pericellular/sinusoidal fibrosis), when present together, indicate the possibility of BCS. |
| format | Article |
| id | doaj-art-3c2179428a9345348c3a8ac0aaa4443f |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-3c2179428a9345348c3a8ac0aaa4443f2025-01-22T15:10:34ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302023-07-016719610110.4103/ijpm.ijpm_325_22Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsiesPallavi PrasadAnurag SinghAlka SinghPrabhaker MishraNarendra KrishnaniBackground: Budd–Chiari syndrome (BCS) requires a constellation of clinical, imaging, and histological findings for diagnosis. Liver biopsy serves as a tool for confirming the diagnosis, even though the histological characteristics are not pathognomonic. Aims: To determine which constellation of morphologic findings could aid in establishing a diagnosis of BCS in clinically suspected cases. Materials and Methods: A 5-year retrospective observational study was conducted. The clinical, laboratory, and histological findings of liver biopsies in patients with a clinical diagnosis of BCS were studied. Cases were segregated into two groups on the basis of the number of histological features present. A scoring system was then devised to assess the efficacy of the histological findings in diagnosing BCS. Statistical Analysis Used: The continuous variables were compared using the Mann–Whitney U-test, and categorical variables were compared using the Fisher-exact test. Results: The common histopathological findings were the presence of red blood cells in the space of disse (100%), peri-portal fibrosis (97.1%), sinusoidal dilation (97.1%), portal inflammation (67.6%), centrilobular necrosis (61.8%) and pericellular/sinusoidal fibrosis (61.8%). Comparison between the two groups showed that centrilobular necrosis, lobular inflammation, portal inflammation, central vein fibrosis, and pericellular/sinusoidal fibrosis were significant parameters. No correlation was found between the clinical and laboratory parameters and the two groups. Conclusions: The liver biopsy features in BCS are often nonspecific, and no single feature in isolation is characteristic. A constellation of features (centrilobular necrosis, lobular inflammation, portal inflammation, central vein fibrosis, and pericellular/sinusoidal fibrosis), when present together, indicate the possibility of BCS.https://journals.lww.com/10.4103/ijpm.ijpm_325_22budd–chiari syndromecentrilobular necrosishistologyliver biopsyscoringsinusoidal dilatation |
| spellingShingle | Pallavi Prasad Anurag Singh Alka Singh Prabhaker Mishra Narendra Krishnani Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies Indian Journal of Pathology and Microbiology budd–chiari syndrome centrilobular necrosis histology liver biopsy scoring sinusoidal dilatation |
| title | Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies |
| title_full | Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies |
| title_fullStr | Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies |
| title_full_unstemmed | Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies |
| title_short | Significance of histopathological features in the diagnosis of Budd–Chiari syndrome on liver biopsies |
| title_sort | significance of histopathological features in the diagnosis of budd chiari syndrome on liver biopsies |
| topic | budd–chiari syndrome centrilobular necrosis histology liver biopsy scoring sinusoidal dilatation |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_325_22 |
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