First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study
Abstract Precise resection of orbital tumors is a critically important but elusive issue. Fluorescence imaging in the near‐infrared II window (NIR‐II) holds the potential to provide the surgeons with real‐time identification for orbital tumors. Here, for the first time, we evaluated the feasibility...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-01-01
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| Series: | Interdisciplinary Medicine |
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| Online Access: | https://doi.org/10.1002/INMD.20240048 |
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| author | Zeyu Zhang Lishuang Guo Lan Yao Yueyue Li Yan Hei Qi Wang Xiaoyi Wang Rui Ma Xinji Yang Zhenhua Hu Wei Wu |
| author_facet | Zeyu Zhang Lishuang Guo Lan Yao Yueyue Li Yan Hei Qi Wang Xiaoyi Wang Rui Ma Xinji Yang Zhenhua Hu Wei Wu |
| author_sort | Zeyu Zhang |
| collection | DOAJ |
| description | Abstract Precise resection of orbital tumors is a critically important but elusive issue. Fluorescence imaging in the near‐infrared II window (NIR‐II) holds the potential to provide the surgeons with real‐time identification for orbital tumors. Here, for the first time, we evaluated the feasibility and clinical value of NIR‐II fluorescence imaging in orbital tumor surgery. To establish the method of NIR‐II fluorescence imaging for orbital tumors, we developed a NIR‐II fluorescence imaging system and indocyanine green (ICG) served as the fluorescent contrast agent. Twenty‐two patients diagnosed with orbital tumors and scheduled for standard‐of‐care surgery were enrolled in this study. Time‐course NIR‐II fluorescence imaging of two patients with superficial orbital tumors showed the optimum imaging time was 2 h post injection of ICG. Fifteen patients were allocated for diagnostic test, which showed that both the in situ and ex vivo NIR‐II fluorescence imaging showed better sensitivity and specificity than the surgeon judgment. In the feasibility trial of the remaining five patients, the surgeon encountered 34 suspicious regions and surgical decisions were changed nine times due to NIR‐II fluorescence imaging. The resultant seven additional resections were justified by histopathology and the two conservative treatments did not result in recurrence. Based on these findings, we suggested that ICG‐based NIR‐II fluorescence imaging was feasible to guide precise resection of orbital tumors. A future randomized controlled trial with a larger cohort is encouraged to further verify the clinical value. |
| format | Article |
| id | doaj-art-3c1b835bc4404d1ca11d7596d0697b29 |
| institution | Kabale University |
| issn | 2832-6245 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Interdisciplinary Medicine |
| spelling | doaj-art-3c1b835bc4404d1ca11d7596d0697b292025-01-25T17:57:32ZengWiley-VCHInterdisciplinary Medicine2832-62452025-01-0131n/an/a10.1002/INMD.20240048First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility studyZeyu Zhang0Lishuang Guo1Lan Yao2Yueyue Li3Yan Hei4Qi Wang5Xiaoyi Wang6Rui Ma7Xinji Yang8Zhenhua Hu9Wei Wu10School of Engineering Medicine Beijing Advanced Innovation Center for Big Data‐Based Precision Medicine Beihang University Beijing ChinaSchool of Engineering Medicine Beijing Advanced Innovation Center for Big Data‐Based Precision Medicine Beihang University Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaCAS Key Laboratory of Molecular Imaging, Beijing Key Laboratory of Molecular Imaging, and State Key Laboratory Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing ChinaSenior Department of Ophthalmology 3rd Medical Center of Chinese PLA General Hospital Beijing ChinaAbstract Precise resection of orbital tumors is a critically important but elusive issue. Fluorescence imaging in the near‐infrared II window (NIR‐II) holds the potential to provide the surgeons with real‐time identification for orbital tumors. Here, for the first time, we evaluated the feasibility and clinical value of NIR‐II fluorescence imaging in orbital tumor surgery. To establish the method of NIR‐II fluorescence imaging for orbital tumors, we developed a NIR‐II fluorescence imaging system and indocyanine green (ICG) served as the fluorescent contrast agent. Twenty‐two patients diagnosed with orbital tumors and scheduled for standard‐of‐care surgery were enrolled in this study. Time‐course NIR‐II fluorescence imaging of two patients with superficial orbital tumors showed the optimum imaging time was 2 h post injection of ICG. Fifteen patients were allocated for diagnostic test, which showed that both the in situ and ex vivo NIR‐II fluorescence imaging showed better sensitivity and specificity than the surgeon judgment. In the feasibility trial of the remaining five patients, the surgeon encountered 34 suspicious regions and surgical decisions were changed nine times due to NIR‐II fluorescence imaging. The resultant seven additional resections were justified by histopathology and the two conservative treatments did not result in recurrence. Based on these findings, we suggested that ICG‐based NIR‐II fluorescence imaging was feasible to guide precise resection of orbital tumors. A future randomized controlled trial with a larger cohort is encouraged to further verify the clinical value.https://doi.org/10.1002/INMD.20240048fluorescence imagingICGNIR‐II imagingorbital tumor |
| spellingShingle | Zeyu Zhang Lishuang Guo Lan Yao Yueyue Li Yan Hei Qi Wang Xiaoyi Wang Rui Ma Xinji Yang Zhenhua Hu Wei Wu First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study Interdisciplinary Medicine fluorescence imaging ICG NIR‐II imaging orbital tumor |
| title | First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study |
| title_full | First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study |
| title_fullStr | First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study |
| title_full_unstemmed | First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study |
| title_short | First‐in‐human orbital tumor surgery guided by near‐infrared II window fluorescence imaging: A feasibility study |
| title_sort | first in human orbital tumor surgery guided by near infrared ii window fluorescence imaging a feasibility study |
| topic | fluorescence imaging ICG NIR‐II imaging orbital tumor |
| url | https://doi.org/10.1002/INMD.20240048 |
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