Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches

Predicting deamidation and isomerization sites in therapeutic antibodies using structure-based in silico approaches

Asparagine (Asn) deamidation and aspartic acid (Asp) isomerization are common degradation pathways that affect the stability of therapeutic antibodies. These modifications can pose a significant challenge in the development of biopharmaceuticals. As such, the early engineering and selection of chemi...

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Bibliographic Details
Main Authors: David Hoffmann, Joschka Bauer, Markus Kossner, Andrew Henry, Anne R. Karow-Zwick, Giuseppe Licari
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:mAbs
Subjects:
Deamidation
developability
in silico methods
isomerization
quantitative structure-activity relationship
therapeutic antibody
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2024.2333436
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