Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin
Kikuchi–Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign, self-limiting disorder of unknown etiology. Mostly prevalent among Asian women, KFD manifests mostly with cervical and rarely generalized or retroperitoneal lymphadenopathy in addition to fever. It can closel...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2018;volume=13;issue=1;spage=56;epage=59;aulast=Padhan |
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| _version_ | 1832544189503504384 |
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| author | Prasanta Padhan Krishna Prasad Tripathy Saroj Ranjan Sahoo Debasish Maikup Nachiketa Mahapatra |
| author_facet | Prasanta Padhan Krishna Prasad Tripathy Saroj Ranjan Sahoo Debasish Maikup Nachiketa Mahapatra |
| author_sort | Prasanta Padhan |
| collection | DOAJ |
| description | Kikuchi–Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign, self-limiting disorder of unknown etiology. Mostly prevalent among Asian women, KFD manifests mostly with cervical and rarely generalized or retroperitoneal lymphadenopathy in addition to fever. It can closely mimic infective and immunological disorders. Here, we report a 23-year-old female who presented with fever of unknown origin with other constitutional symptoms. The infectious and malignancy screen was negative on extensive workup. The patient was found to have multiple abdominal and cervical lymph nodes on imaging, biopsy and immunohistochemistry revealed histiocytic necrotizing lymphadenitis, which confirmed the diagnosis of KFD. Although rare, clinicians should be aware of KFD condition, as early recognition of the disease will minimize potentially harmful and unnecessary evaluation and treatments. |
| format | Article |
| id | doaj-art-3bfd3feffa1b481087c8ab7f8a8b7150 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-3bfd3feffa1b481087c8ab7f8a8b71502025-02-03T10:51:13ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012018-01-01131565910.4103/injr.injr_101_17Kikuchi–Fujimoto disease presenting as pyrexia of unknown originPrasanta PadhanKrishna Prasad TripathySaroj Ranjan SahooDebasish MaikupNachiketa MahapatraKikuchi–Fujimoto disease (KFD), or histiocytic necrotizing lymphadenitis, is a rare benign, self-limiting disorder of unknown etiology. Mostly prevalent among Asian women, KFD manifests mostly with cervical and rarely generalized or retroperitoneal lymphadenopathy in addition to fever. It can closely mimic infective and immunological disorders. Here, we report a 23-year-old female who presented with fever of unknown origin with other constitutional symptoms. The infectious and malignancy screen was negative on extensive workup. The patient was found to have multiple abdominal and cervical lymph nodes on imaging, biopsy and immunohistochemistry revealed histiocytic necrotizing lymphadenitis, which confirmed the diagnosis of KFD. Although rare, clinicians should be aware of KFD condition, as early recognition of the disease will minimize potentially harmful and unnecessary evaluation and treatments.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2018;volume=13;issue=1;spage=56;epage=59;aulast=PadhanHistiocytic necrotizing lymphadenitisKikuchi-Fujimoto diseaseSystemic lupus erythematosus |
| spellingShingle | Prasanta Padhan Krishna Prasad Tripathy Saroj Ranjan Sahoo Debasish Maikup Nachiketa Mahapatra Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin Indian Journal of Rheumatology Histiocytic necrotizing lymphadenitis Kikuchi-Fujimoto disease Systemic lupus erythematosus |
| title | Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin |
| title_full | Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin |
| title_fullStr | Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin |
| title_full_unstemmed | Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin |
| title_short | Kikuchi–Fujimoto disease presenting as pyrexia of unknown origin |
| title_sort | kikuchi fujimoto disease presenting as pyrexia of unknown origin |
| topic | Histiocytic necrotizing lymphadenitis Kikuchi-Fujimoto disease Systemic lupus erythematosus |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2018;volume=13;issue=1;spage=56;epage=59;aulast=Padhan |
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