Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice
Gout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. Recent research has provided evidence of distinct differences in the gut microbiota of...
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eLife Sciences Publications Ltd
2025-02-01
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| Online Access: | https://elifesciences.org/articles/98714 |
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| author | Ning Song Hang Gao Jianhao Li Yi Liu Mingze Wang Zhiming Ma Naisheng Zhang Wenlong Zhang |
| author_facet | Ning Song Hang Gao Jianhao Li Yi Liu Mingze Wang Zhiming Ma Naisheng Zhang Wenlong Zhang |
| author_sort | Ning Song |
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| description | Gout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. Recent research has provided evidence of distinct differences in the gut microbiota of patients with gout and hyperuricemia compared to healthy individuals. However, the link between gut microbiota and age-related gout remained underexplored. Our study found that gut microbiota plays a crucial role in determining susceptibility to age-related gout. Specifically, we observed that age-related gut microbiota regulated the activation of the NLRP3 inflammasome pathway and modulated uric acid metabolism. More scrutiny highlighted the positive impact of ‘younger’ microbiota on the gut microbiota structure of old or aged mice, enhancing butanoate metabolism and butyric acid content. Experimentation with butyrate supplementation indicated that butyric acid exerts a dual effect, inhibiting inflammation in acute gout and reducing serum uric acid levels. These insights emphasize the potential of gut microbiome rejuvenation in mitigating senile gout, unraveling the intricate dynamics between microbiota, aging, and gout. It potentially serves as a therapeutic target for senile gout-related conditions. |
| format | Article |
| id | doaj-art-3bfc9cfb8edd4e148447fa3db9ea5ed7 |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | eLife Sciences Publications Ltd |
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| spelling | doaj-art-3bfc9cfb8edd4e148447fa3db9ea5ed72025-02-05T15:39:51ZengeLife Sciences Publications LtdeLife2050-084X2025-02-011310.7554/eLife.98714Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged miceNing Song0Hang Gao1Jianhao Li2Yi Liu3Mingze Wang4Zhiming Ma5Naisheng Zhang6Wenlong Zhang7https://orcid.org/0000-0002-6313-2241Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Bone and Joint Surgery, No 1 Hospital of Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Bone and Joint Surgery, No 1 Hospital of Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaDepartment of Clinical Veterinary Medicine, College of Veterinary Medicine, Jilin University, Changchun, ChinaGout is a prevalent form of inflammatory arthritis that occurs due to high levels of uric acid in the blood leading to the formation of urate crystals in and around the joints, particularly affecting the elderly. Recent research has provided evidence of distinct differences in the gut microbiota of patients with gout and hyperuricemia compared to healthy individuals. However, the link between gut microbiota and age-related gout remained underexplored. Our study found that gut microbiota plays a crucial role in determining susceptibility to age-related gout. Specifically, we observed that age-related gut microbiota regulated the activation of the NLRP3 inflammasome pathway and modulated uric acid metabolism. More scrutiny highlighted the positive impact of ‘younger’ microbiota on the gut microbiota structure of old or aged mice, enhancing butanoate metabolism and butyric acid content. Experimentation with butyrate supplementation indicated that butyric acid exerts a dual effect, inhibiting inflammation in acute gout and reducing serum uric acid levels. These insights emphasize the potential of gut microbiome rejuvenation in mitigating senile gout, unraveling the intricate dynamics between microbiota, aging, and gout. It potentially serves as a therapeutic target for senile gout-related conditions.https://elifesciences.org/articles/98714gouthyperuricemiagut microbeagebutyrate |
| spellingShingle | Ning Song Hang Gao Jianhao Li Yi Liu Mingze Wang Zhiming Ma Naisheng Zhang Wenlong Zhang Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice eLife gout hyperuricemia gut microbe age butyrate |
| title | Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice |
| title_full | Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice |
| title_fullStr | Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice |
| title_full_unstemmed | Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice |
| title_short | Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice |
| title_sort | microbiota from young mice counteracts susceptibility to age related gout through modulating butyric acid levels in aged mice |
| topic | gout hyperuricemia gut microbe age butyrate |
| url | https://elifesciences.org/articles/98714 |
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