Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence
Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of an impaired NK cell functionality on the increased colon cancer ris...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Nutrition and Metabolism |
| Online Access: | http://dx.doi.org/10.1155/2017/4297025 |
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| _version_ | 1832549499434696704 |
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| author | Ina Bähr Vincent Goritz Henriette Doberstein Grit Gesine Ruth Hiller Philip Rosenstock Janine Jahn Ole Pörtner Tobias Berreis Thomas Mueller Julia Spielmann Heike Kielstein |
| author_facet | Ina Bähr Vincent Goritz Henriette Doberstein Grit Gesine Ruth Hiller Philip Rosenstock Janine Jahn Ole Pörtner Tobias Berreis Thomas Mueller Julia Spielmann Heike Kielstein |
| author_sort | Ina Bähr |
| collection | DOAJ |
| description | Obesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of an impaired NK cell functionality on the increased colon cancer risk in obesity. In vitro investigations demonstrated a decreased IFN-γ secretion and cytotoxicity of human NK cells against colon tumor cells after NK cell preincubation with the adipokine leptin. In addition, leptin incubation decreased the expression of activating NK cell receptors. In animal studies, colon cancer growth was induced by injection of azoxymethane (AOM) in normal weight and diet-induced obese rats. Body weight and visceral fat mass were increased in obese animals compared to normal weight rats. AOM-treated obese rats showed an increased quantity, size, and weight of colon tumors compared to the normal weight tumor group. Immunohistochemical analyses demonstrated a decreased number of NK cells in spleen and liver in obesity. Additionally, the expression levels of activating NK cell receptors were lower in spleen and liver of obese rats. The results show for the first time that the decreased number and impaired NK cell function may be one cause for the higher colon cancer risk in obesity. |
| format | Article |
| id | doaj-art-3bfbd7da977e413ca5c8fd6d4ec23457 |
| institution | Kabale University |
| issn | 2090-0724 2090-0732 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nutrition and Metabolism |
| spelling | doaj-art-3bfbd7da977e413ca5c8fd6d4ec234572025-02-03T06:11:06ZengWileyJournal of Nutrition and Metabolism2090-07242090-07322017-01-01201710.1155/2017/42970254297025Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer IncidenceIna Bähr0Vincent Goritz1Henriette Doberstein2Grit Gesine Ruth Hiller3Philip Rosenstock4Janine Jahn5Ole Pörtner6Tobias Berreis7Thomas Mueller8Julia Spielmann9Heike Kielstein10Institute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Pathology, University Hospital of Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyClinic for Internal Medicine IV, Department of Hematology and Oncology, University Hospital of Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyInstitute of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Halle (Saale), GermanyObesity is associated with an increased colon cancer incidence, but underlying mechanisms remained unclear. Previous studies showed altered Natural killer (NK) cell functions in obese individuals. Therefore, we studied the impact of an impaired NK cell functionality on the increased colon cancer risk in obesity. In vitro investigations demonstrated a decreased IFN-γ secretion and cytotoxicity of human NK cells against colon tumor cells after NK cell preincubation with the adipokine leptin. In addition, leptin incubation decreased the expression of activating NK cell receptors. In animal studies, colon cancer growth was induced by injection of azoxymethane (AOM) in normal weight and diet-induced obese rats. Body weight and visceral fat mass were increased in obese animals compared to normal weight rats. AOM-treated obese rats showed an increased quantity, size, and weight of colon tumors compared to the normal weight tumor group. Immunohistochemical analyses demonstrated a decreased number of NK cells in spleen and liver in obesity. Additionally, the expression levels of activating NK cell receptors were lower in spleen and liver of obese rats. The results show for the first time that the decreased number and impaired NK cell function may be one cause for the higher colon cancer risk in obesity.http://dx.doi.org/10.1155/2017/4297025 |
| spellingShingle | Ina Bähr Vincent Goritz Henriette Doberstein Grit Gesine Ruth Hiller Philip Rosenstock Janine Jahn Ole Pörtner Tobias Berreis Thomas Mueller Julia Spielmann Heike Kielstein Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence Journal of Nutrition and Metabolism |
| title | Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence |
| title_full | Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence |
| title_fullStr | Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence |
| title_full_unstemmed | Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence |
| title_short | Diet-Induced Obesity Is Associated with an Impaired NK Cell Function and an Increased Colon Cancer Incidence |
| title_sort | diet induced obesity is associated with an impaired nk cell function and an increased colon cancer incidence |
| url | http://dx.doi.org/10.1155/2017/4297025 |
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