The Association of Metabolic Syndrome and Urolithiasis
There has been an increasing prevalence of kidney stones over the last 2 decades worldwide. Many studies have indicated a possible association between metabolic syndrome and kidney stone disease, particularly in overweight and obese patients. Many different definitions of metabolic syndrome have bee...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/570674 |
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| author | Yee V. Wong Paul Cook Bhaskar K. Somani |
| author_facet | Yee V. Wong Paul Cook Bhaskar K. Somani |
| author_sort | Yee V. Wong |
| collection | DOAJ |
| description | There has been an increasing prevalence of kidney stones over the last 2 decades worldwide. Many studies have indicated a possible association between metabolic syndrome and kidney stone disease, particularly in overweight and obese patients. Many different definitions of metabolic syndrome have been suggested by various organizations, although the definition by the International Diabetes Federation (IDF) is universally considered as the most acceptable definition. The IDF definition revolves around 4 core components: obesity, dyslipidemia, hypertension, and diabetes mellitus. Several hypotheses have been proposed to explain the pathophysiology of urolithiasis resulting from metabolic syndrome, amongst which are the insulin resistance and Randall’s plaque hypothesis. Similarly the pathophysiology of calcium and uric acid stone formation has been investigated to determine a connection between the two conditions. Studies have found many factors contributing to urolithiasis in patients suffering from metabolic syndrome, out of which obesity, overweight, and sedentary lifestyles have been identified as major etiological factors. Primary and secondary prevention methods therefore tend to revolve mainly around lifestyle improvements, including dietary and other preventive measures. |
| format | Article |
| id | doaj-art-3bf868bade0b4839b7ca88b9b0b1d003 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-3bf868bade0b4839b7ca88b9b0b1d0032025-02-03T01:22:37ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/570674570674The Association of Metabolic Syndrome and UrolithiasisYee V. Wong0Paul Cook1Bhaskar K. Somani2Department of Urology, University Hospital Southampton NHS Trust, Southampton SO16 6YD, UKDepartment of Biochemical Pathology, University Hospital Southampton NHS Trust, Southampton SO16 6YD, UKDepartment of Urology, University Hospital Southampton NHS Trust, Southampton SO16 6YD, UKThere has been an increasing prevalence of kidney stones over the last 2 decades worldwide. Many studies have indicated a possible association between metabolic syndrome and kidney stone disease, particularly in overweight and obese patients. Many different definitions of metabolic syndrome have been suggested by various organizations, although the definition by the International Diabetes Federation (IDF) is universally considered as the most acceptable definition. The IDF definition revolves around 4 core components: obesity, dyslipidemia, hypertension, and diabetes mellitus. Several hypotheses have been proposed to explain the pathophysiology of urolithiasis resulting from metabolic syndrome, amongst which are the insulin resistance and Randall’s plaque hypothesis. Similarly the pathophysiology of calcium and uric acid stone formation has been investigated to determine a connection between the two conditions. Studies have found many factors contributing to urolithiasis in patients suffering from metabolic syndrome, out of which obesity, overweight, and sedentary lifestyles have been identified as major etiological factors. Primary and secondary prevention methods therefore tend to revolve mainly around lifestyle improvements, including dietary and other preventive measures.http://dx.doi.org/10.1155/2015/570674 |
| spellingShingle | Yee V. Wong Paul Cook Bhaskar K. Somani The Association of Metabolic Syndrome and Urolithiasis International Journal of Endocrinology |
| title | The Association of Metabolic Syndrome and Urolithiasis |
| title_full | The Association of Metabolic Syndrome and Urolithiasis |
| title_fullStr | The Association of Metabolic Syndrome and Urolithiasis |
| title_full_unstemmed | The Association of Metabolic Syndrome and Urolithiasis |
| title_short | The Association of Metabolic Syndrome and Urolithiasis |
| title_sort | association of metabolic syndrome and urolithiasis |
| url | http://dx.doi.org/10.1155/2015/570674 |
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