Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands
Background: Gastric carcinoma in the Tervueren and Groenendael varieties of the Belgian Shepherd dog is commonly recognized and carries a grave prognosis. Information on incidence and heritability is necessary to design an effective selection strategy against this disease. Methods: A database of cas...
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2025-01-01
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| author | Sanne Hugen Citlalli Limpens Joris H. Robben Hille Fieten Paul J. J. Mandigers |
| author_facet | Sanne Hugen Citlalli Limpens Joris H. Robben Hille Fieten Paul J. J. Mandigers |
| author_sort | Sanne Hugen |
| collection | DOAJ |
| description | Background: Gastric carcinoma in the Tervueren and Groenendael varieties of the Belgian Shepherd dog is commonly recognized and carries a grave prognosis. Information on incidence and heritability is necessary to design an effective selection strategy against this disease. Methods: A database of cases and controls was built including cases with Tier 1 (confirmed via endoscopy or post-mortem) and Tier 2 evidence of gastric carcinoma. From the database, a birth cohort of dogs born in the Netherlands in the period 2000–2010 was used, together with pedigree information to calculate heritability using a mixed models approach. Univariate linear regression was used to test the influence of the gastric carcinoma status of the parents on gastric carcinoma occurrence in offspring. Results: For Tervueren the 10-year cumulative incidence was 4.7%, and for the Groenendael this was 2.1%. There was no sex predilection. The odds of gastric carcinoma were 5.0 (2.4–11.0) in offspring where at least one parent was known to be affected versus at least one parent was known to be unaffected. Heritability, based on analysis using pedigree information from 338 dogs with gastric carcinoma and 159 controls, was 0.53 (SE 0.15). Conclusions: Gastric carcinoma in the Belgian Shepherd Tervueren and Groenendael varieties has a high incidence in the Dutch population and a strong genetic component. Because it is a late onset disease, dogs have often already been used for breeding before they are diagnosed. An effective breeding strategy for reducing disease incidence therefore relies on the identification of genetic risk factors influencing its development. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-3bce7c79775044f2ab786ff6754aaa5c2025-01-24T13:52:00ZengMDPI AGVeterinary Sciences2306-73812025-01-011211810.3390/vetsci12010018Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The NetherlandsSanne Hugen0Citlalli Limpens1Joris H. Robben2Hille Fieten3Paul J. J. Mandigers4Department of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The NetherlandsDepartment of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The NetherlandsDepartment of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The NetherlandsDepartment of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The NetherlandsDepartment of Clinical Sciences of Companion animals, Faculty of Veterinary Medicine, Utrecht University, 3584 CL Utrecht, The NetherlandsBackground: Gastric carcinoma in the Tervueren and Groenendael varieties of the Belgian Shepherd dog is commonly recognized and carries a grave prognosis. Information on incidence and heritability is necessary to design an effective selection strategy against this disease. Methods: A database of cases and controls was built including cases with Tier 1 (confirmed via endoscopy or post-mortem) and Tier 2 evidence of gastric carcinoma. From the database, a birth cohort of dogs born in the Netherlands in the period 2000–2010 was used, together with pedigree information to calculate heritability using a mixed models approach. Univariate linear regression was used to test the influence of the gastric carcinoma status of the parents on gastric carcinoma occurrence in offspring. Results: For Tervueren the 10-year cumulative incidence was 4.7%, and for the Groenendael this was 2.1%. There was no sex predilection. The odds of gastric carcinoma were 5.0 (2.4–11.0) in offspring where at least one parent was known to be affected versus at least one parent was known to be unaffected. Heritability, based on analysis using pedigree information from 338 dogs with gastric carcinoma and 159 controls, was 0.53 (SE 0.15). Conclusions: Gastric carcinoma in the Belgian Shepherd Tervueren and Groenendael varieties has a high incidence in the Dutch population and a strong genetic component. Because it is a late onset disease, dogs have often already been used for breeding before they are diagnosed. An effective breeding strategy for reducing disease incidence therefore relies on the identification of genetic risk factors influencing its development.https://www.mdpi.com/2306-7381/12/1/18stomach cancerpopulation geneticstervuerenBelgian sheepdoggroenendael |
| spellingShingle | Sanne Hugen Citlalli Limpens Joris H. Robben Hille Fieten Paul J. J. Mandigers Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands Veterinary Sciences stomach cancer population genetics tervueren Belgian sheepdog groenendael |
| title | Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands |
| title_full | Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands |
| title_fullStr | Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands |
| title_full_unstemmed | Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands |
| title_short | Incidence and Heritability of Gastric Carcinoma in the Belgian Shepherd Dog Population in The Netherlands |
| title_sort | incidence and heritability of gastric carcinoma in the belgian shepherd dog population in the netherlands |
| topic | stomach cancer population genetics tervueren Belgian sheepdog groenendael |
| url | https://www.mdpi.com/2306-7381/12/1/18 |
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