Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations
Stroke remains a disease with a serious impact on quality of life but few effective treatments exist. There is an urgent need to develop and/or improve neuroprotective strategies to combat this. Many drugs proven to be neuroprotective in experimental models fail to improve patient outcome in a clini...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
|
| Series: | Stroke Research and Treatment |
| Online Access: | http://dx.doi.org/10.4061/2011/689290 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554076573794304 |
|---|---|
| author | Tine Zgavc An-Gaëlle Ceulemans Sophie Sarre Yvette Michotte Said Hachimi-Idrissi |
| author_facet | Tine Zgavc An-Gaëlle Ceulemans Sophie Sarre Yvette Michotte Said Hachimi-Idrissi |
| author_sort | Tine Zgavc |
| collection | DOAJ |
| description | Stroke remains a disease with a serious impact on quality of life but few effective treatments exist. There is an urgent need to develop and/or improve neuroprotective strategies to combat this. Many drugs proven to be neuroprotective in experimental models fail to improve patient outcome in a clinical setting. An emerging treatment, therapeutic hypothermia (TH), is a promising neuroprotective therapy in stroke management. Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. This paper discusses the possible opportunities and limitations of the use of TH in animal models and the translation into the clinic. |
| format | Article |
| id | doaj-art-3bbe83b58bbc4d3c9048b591954077d2 |
| institution | Kabale University |
| issn | 2042-0056 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke Research and Treatment |
| spelling | doaj-art-3bbe83b58bbc4d3c9048b591954077d22025-02-03T05:52:22ZengWileyStroke Research and Treatment2042-00562011-01-01201110.4061/2011/689290689290Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and LimitationsTine Zgavc0An-Gaëlle Ceulemans1Sophie Sarre2Yvette Michotte3Said Hachimi-Idrissi4Department of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumDepartment of Pharmaceutical Chemistry and Drug Analysis, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumCritical Care Department and Cerebral Resuscitation Research Group, Center for Neuroscience, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, BelgiumStroke remains a disease with a serious impact on quality of life but few effective treatments exist. There is an urgent need to develop and/or improve neuroprotective strategies to combat this. Many drugs proven to be neuroprotective in experimental models fail to improve patient outcome in a clinical setting. An emerging treatment, therapeutic hypothermia (TH), is a promising neuroprotective therapy in stroke management. Several studies with TH in experimental models and small clinical trials have shown beneficial effects. Despite this, implementation into the clinical setting is still lacking due to methodological considerations as well as hypothermia-related complications. This paper discusses the possible opportunities and limitations of the use of TH in animal models and the translation into the clinic.http://dx.doi.org/10.4061/2011/689290 |
| spellingShingle | Tine Zgavc An-Gaëlle Ceulemans Sophie Sarre Yvette Michotte Said Hachimi-Idrissi Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations Stroke Research and Treatment |
| title | Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations |
| title_full | Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations |
| title_fullStr | Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations |
| title_full_unstemmed | Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations |
| title_short | Experimental and Clinical Use of Therapeutic Hypothermia for Ischemic Stroke: Opportunities and Limitations |
| title_sort | experimental and clinical use of therapeutic hypothermia for ischemic stroke opportunities and limitations |
| url | http://dx.doi.org/10.4061/2011/689290 |
| work_keys_str_mv | AT tinezgavc experimentalandclinicaluseoftherapeutichypothermiaforischemicstrokeopportunitiesandlimitations AT angaelleceulemans experimentalandclinicaluseoftherapeutichypothermiaforischemicstrokeopportunitiesandlimitations AT sophiesarre experimentalandclinicaluseoftherapeutichypothermiaforischemicstrokeopportunitiesandlimitations AT yvettemichotte experimentalandclinicaluseoftherapeutichypothermiaforischemicstrokeopportunitiesandlimitations AT saidhachimiidrissi experimentalandclinicaluseoftherapeutichypothermiaforischemicstrokeopportunitiesandlimitations |