Tissue‐resident memory T cells in diseases and therapeutic strategies
Abstract Tissue‐resident memory T (TRM) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, TRM cells are located within peripheral tissues, and they play vital roles i...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | MedComm |
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| Online Access: | https://doi.org/10.1002/mco2.70053 |
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| author | Daoyuan Xie Guanting Lu Gang Mai Qiuyan Guo Guofeng Xu |
| author_facet | Daoyuan Xie Guanting Lu Gang Mai Qiuyan Guo Guofeng Xu |
| author_sort | Daoyuan Xie |
| collection | DOAJ |
| description | Abstract Tissue‐resident memory T (TRM) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, TRM cells are located within peripheral tissues, and they play vital roles in antiviral, antibacterial, and antitumor immunity. Their unique retention and activation mechanisms, including interactions with local epithelial cells and the expression of adhesion molecules, enable their persistence and immediate functionality in diverse tissues. Recent advances have revealed their important roles in chronic inflammation, autoimmunity, and cancer, illuminating both their protective and their pathogenic potential. This review synthesizes current knowledge on TRM cells’ molecular signatures, maintenance pathways, and functional dynamics across different tissues. We also explore the interactions of TRM cells with other immune cells, such as B cells, macrophages, and dendritic cells, highlighting the complex network that underpins the efficacy of TRM cells in immune surveillance and response. Understanding the nuanced regulation of TRM cells is essential for developing targeted therapeutic strategies, including vaccines and immunotherapies, to enhance their protective roles while mitigating adverse effects. Insights into TRM cells’ biology hold promise for innovative treatments for infectious diseases, cancer, and autoimmune conditions. |
| format | Article |
| id | doaj-art-3bb6c5663bf64775bc6edd142712e584 |
| institution | Kabale University |
| issn | 2688-2663 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj-art-3bb6c5663bf64775bc6edd142712e5842025-01-20T01:45:44ZengWileyMedComm2688-26632025-01-0161n/an/a10.1002/mco2.70053Tissue‐resident memory T cells in diseases and therapeutic strategiesDaoyuan Xie0Guanting Lu1Gang Mai2Qiuyan Guo3Guofeng Xu4Laboratory of Translational Medicine Research Deyang People's Hospital of Chengdu University of Traditional Chinese Medicine Deyang ChinaLaboratory of Translational Medicine Research Deyang People's Hospital of Chengdu University of Traditional Chinese Medicine Deyang ChinaLaboratory of Translational Medicine Research Deyang People's Hospital of Chengdu University of Traditional Chinese Medicine Deyang ChinaState Key Laboratory for Quality Ensurance and Sustainable Use of Dao‐di Herbs, Artemisinin Research Center, Institute of Chinese Materia Medica Academy of Chinese Medical Sciences Beijing ChinaInflammation & Allergic Diseases Research Unit The Affiliated Hospital of Southwest Medical University Luzhou ChinaAbstract Tissue‐resident memory T (TRM) cells are crucial components of the immune system that provide rapid, localized responses to recurrent pathogens at mucosal and epithelial barriers. Unlike circulating memory T cells, TRM cells are located within peripheral tissues, and they play vital roles in antiviral, antibacterial, and antitumor immunity. Their unique retention and activation mechanisms, including interactions with local epithelial cells and the expression of adhesion molecules, enable their persistence and immediate functionality in diverse tissues. Recent advances have revealed their important roles in chronic inflammation, autoimmunity, and cancer, illuminating both their protective and their pathogenic potential. This review synthesizes current knowledge on TRM cells’ molecular signatures, maintenance pathways, and functional dynamics across different tissues. We also explore the interactions of TRM cells with other immune cells, such as B cells, macrophages, and dendritic cells, highlighting the complex network that underpins the efficacy of TRM cells in immune surveillance and response. Understanding the nuanced regulation of TRM cells is essential for developing targeted therapeutic strategies, including vaccines and immunotherapies, to enhance their protective roles while mitigating adverse effects. Insights into TRM cells’ biology hold promise for innovative treatments for infectious diseases, cancer, and autoimmune conditions.https://doi.org/10.1002/mco2.70053tissue‐resident memory T (TRM) cellstherapeutic targetingneoadjuvant therapyvaccineimmunotherapy |
| spellingShingle | Daoyuan Xie Guanting Lu Gang Mai Qiuyan Guo Guofeng Xu Tissue‐resident memory T cells in diseases and therapeutic strategies MedComm tissue‐resident memory T (TRM) cells therapeutic targeting neoadjuvant therapy vaccine immunotherapy |
| title | Tissue‐resident memory T cells in diseases and therapeutic strategies |
| title_full | Tissue‐resident memory T cells in diseases and therapeutic strategies |
| title_fullStr | Tissue‐resident memory T cells in diseases and therapeutic strategies |
| title_full_unstemmed | Tissue‐resident memory T cells in diseases and therapeutic strategies |
| title_short | Tissue‐resident memory T cells in diseases and therapeutic strategies |
| title_sort | tissue resident memory t cells in diseases and therapeutic strategies |
| topic | tissue‐resident memory T (TRM) cells therapeutic targeting neoadjuvant therapy vaccine immunotherapy |
| url | https://doi.org/10.1002/mco2.70053 |
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