Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies

Novel thiazolyl-pyrimidine derivatives as potential anticancer agents: Synthesis, biological evaluation, and molecular docking studies

We synthesized and spectroscopically confirmed a series of 1,3-thiazolyl-pyrimidine derivatives to investigate their potential role in cancer therapy. These were created by reacting 2-(1-(6-methyl-2-oxo-4-phenyl- 1,2,3,4-tetrahydropyrimidin-5-yl)ethylidene)hydrazine-1-carbothioamide with hydrazonoyl...

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Bibliographic Details
Main Authors: Tariq Z. Abolibda, Abdel-Aziz A.A. El-Sayed, Basant Farag, Magdi E.A. Zaki, Abdulwahed Alrehaily, Hossein M. Elbadawy, Ahmad A. Al-Shahri, Saleh R. Alsenani, Sobhi M. Gomha
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Results in Chemistry
Subjects:
Hydrazonothiazoles
Hydrazonoyl chlorides
Anticancer activity
Molecular docking studies and in silico studies
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715624007045
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