The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome
Abstract Background-In Algeria, there is a lack of up-to-date information regarding the burden of diabetes in patients with coronary disease and its long-term prognostic impact. Our objective was to evaluate the long-term prognostic impact of diabetes in the context of contemporary management of pa...
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University of Oran 1
2022-06-01
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| Series: | Journal de la Faculté de Médecine d'Oran |
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| Online Access: | https://www.ajol.info/index.php/jfmo/article/view/227384 |
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| author | Farouk BOUKERCHE Leila HAMMOU Nadia LAREDJ |
| author_facet | Farouk BOUKERCHE Leila HAMMOU Nadia LAREDJ |
| author_sort | Farouk BOUKERCHE |
| collection | DOAJ |
| description |
Abstract
Background-In Algeria, there is a lack of up-to-date information regarding the burden of diabetes
in patients with coronary disease and its long-term prognostic impact. Our objective
was to evaluate the long-term prognostic impact of diabetes in the context of contemporary
management of patients with non-ST elevation acute coronary syndrome including a systematic
interventional approach.
Methods - A prospective study including all patients admitted to the cardiology department
of CHU Oran for non-ST elevation ACS from November 2015 to October 2016 and with a
five-year follow-up, a comparative study was carried out between the known diabetic group
and the non-diabetic group in terms of occurrence of major adverse cardiovascular and
cerebrovascular events.
Results -Of the 296 patients initially included, 274 completed the 5-year follow-up (7.4%
lost at follow-up). The diabetic group included 128 patients (46.7%) and is differentiated
from the non-diabetic group by the female predominance, more hypertension, dyslipidemia,
and obese and fewer smokers, more three-vessel disease, therapeutically more frequent
use of coronary artery bypass grafting. On the prognostic level, there is no significant
difference in cardiovascular mortality (19.5% vs. 12.3%; p=0.134). On the other hand, there
were more major adverse cardiovascular and cerebrovascular events in diabetics (43.0% vs
27.4%; p=0.008). In multivariate analysis, diabetes was an independent risk marker for the
occurrence of major adverse cardiovascular and cerebrovascular events at 5 years, and cardiovascular
mortality at 5 years, it is diabetes with more than 10 years old and not diabetes
in general which, is a prognostic marker.
Conclusion - With contemporary management of non-ST elevation ACS, the prognostic
weight of diabetes persists but tends to decrease.
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| format | Article |
| id | doaj-art-3baf6008e0a84e20a9dde7c107a861cf |
| institution | Kabale University |
| issn | 2571-9874 2602-6511 |
| language | English |
| publishDate | 2022-06-01 |
| publisher | University of Oran 1 |
| record_format | Article |
| series | Journal de la Faculté de Médecine d'Oran |
| spelling | doaj-art-3baf6008e0a84e20a9dde7c107a861cf2025-01-30T19:51:09ZengUniversity of Oran 1Journal de la Faculté de Médecine d'Oran2571-98742602-65112022-06-0161The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndromeFarouk BOUKERCHE0Leila HAMMOU1Nadia LAREDJ2Service de cardiologie, CHU-OranUniversity Oran 1Service de cardiologie, CHU-Oran Abstract Background-In Algeria, there is a lack of up-to-date information regarding the burden of diabetes in patients with coronary disease and its long-term prognostic impact. Our objective was to evaluate the long-term prognostic impact of diabetes in the context of contemporary management of patients with non-ST elevation acute coronary syndrome including a systematic interventional approach. Methods - A prospective study including all patients admitted to the cardiology department of CHU Oran for non-ST elevation ACS from November 2015 to October 2016 and with a five-year follow-up, a comparative study was carried out between the known diabetic group and the non-diabetic group in terms of occurrence of major adverse cardiovascular and cerebrovascular events. Results -Of the 296 patients initially included, 274 completed the 5-year follow-up (7.4% lost at follow-up). The diabetic group included 128 patients (46.7%) and is differentiated from the non-diabetic group by the female predominance, more hypertension, dyslipidemia, and obese and fewer smokers, more three-vessel disease, therapeutically more frequent use of coronary artery bypass grafting. On the prognostic level, there is no significant difference in cardiovascular mortality (19.5% vs. 12.3%; p=0.134). On the other hand, there were more major adverse cardiovascular and cerebrovascular events in diabetics (43.0% vs 27.4%; p=0.008). In multivariate analysis, diabetes was an independent risk marker for the occurrence of major adverse cardiovascular and cerebrovascular events at 5 years, and cardiovascular mortality at 5 years, it is diabetes with more than 10 years old and not diabetes in general which, is a prognostic marker. Conclusion - With contemporary management of non-ST elevation ACS, the prognostic weight of diabetes persists but tends to decrease. https://www.ajol.info/index.php/jfmo/article/view/227384DiabetesNSTE-ACSPrognostic factorsrisk stratification |
| spellingShingle | Farouk BOUKERCHE Leila HAMMOU Nadia LAREDJ The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome Journal de la Faculté de Médecine d'Oran Diabetes NSTE-ACS Prognostic factors risk stratification |
| title | The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome |
| title_full | The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome |
| title_fullStr | The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome |
| title_full_unstemmed | The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome |
| title_short | The Impact of diabetes on long-term prognosis in non-ST elevation acute coronary syndrome |
| title_sort | impact of diabetes on long term prognosis in non st elevation acute coronary syndrome |
| topic | Diabetes NSTE-ACS Prognostic factors risk stratification |
| url | https://www.ajol.info/index.php/jfmo/article/view/227384 |
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