DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cells

DNA methylation changes during acute COVID-19 are associated with long-term transcriptional dysregulation in patients’ airway epithelial cells

Abstract Molecular changes underlying the persistent health effects after SARS-CoV-2 infection remain poorly understood. To discern the gene regulatory landscape in the upper respiratory tract of COVID-19 patients, we performed enzymatic DNA methylome and single-cell RNA sequencing in nasal cells of...

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Main Authors: Marey Messingschlager, Sebastian D Mackowiak, Maria Theresa Voelker, Matthias Bieg, Jennifer Loske, Robert Lorenz Chua, Johannes Liebig, Sören Lukassen, Loreen Thürmann, Anke Seegebarth, Sven Twardziok, Daria Doncevic, Carl Herrmann, Stephan Lorenz, Sven Klages, Fridolin Steinbeis, Martin Witzenrath, Florian Kurth, Christian Conrad, Leif E Sander, Naveed Ishaque, Roland Eils, Irina Lehmann, Sven Laudi, Saskia Trump
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
Subjects:
Whole-genome DNA Methylation Sequencing
scRNA-seq
COVID-19
Post-COVID-19 Condition
Nasal Mucosa
Online Access:https://doi.org/10.1038/s44321-025-00215-5
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https://doi.org/10.1038/s44321-025-00215-5

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