A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6
A 77-year-old woman visited our institution complaining of general fatigue. Chest radiography revealed masses in the upper and middle lung fields. Pathological findings for an endoscopic biopsy specimen revealed squamous cell carcinoma. High-grade fever developed and blood analyses revealed sustaine...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/325127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562937106006016 |
|---|---|
| author | Nobuhiro Takeuchi Kento Yamamoto Kazuyoshi Naba |
| author_facet | Nobuhiro Takeuchi Kento Yamamoto Kazuyoshi Naba |
| author_sort | Nobuhiro Takeuchi |
| collection | DOAJ |
| description | A 77-year-old woman visited our institution complaining of general fatigue. Chest radiography revealed masses in the upper and middle lung fields. Pathological findings for an endoscopic biopsy specimen revealed squamous cell carcinoma. High-grade fever developed and blood analyses revealed sustained elevated white blood cell count and C-reactive protein levels. Cytokine production by tumor cells was suspected; both serum granulocyte colony-stimulating factor (117 pg/mL; normal: <57.5 pg/mL) and interleukin-6 (83.5 pg/mL; normal: <2.41 pg/mL) levels were high. Immunohistochemical examination of biopsy specimens showed positive staining with antigranulocyte colony-stimulating factor and anti-interleukin-6 monoclonal antibodies. Diagnosis of a tumor that produced granulocyte colony-stimulating factor and interleukin-6 was established. The patient was administered best supportive therapy since she was not eligible for surgical treatment because of her poor respiratory function. She died from interstitial pneumonia exacerbation two months after this diagnosis. We present a female with squamous cell carcinoma of the lung that produced granulocyte colony-stimulating factor and interleukin-6. |
| format | Article |
| id | doaj-art-3b8ff4d9f25446c993dcd90906019175 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-3b8ff4d9f25446c993dcd909060191752025-02-03T01:21:25ZengWileyCase Reports in Medicine1687-96271687-96352013-01-01201310.1155/2013/325127325127A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6Nobuhiro Takeuchi0Kento Yamamoto1Kazuyoshi Naba2Department of Internal Medicine, Kawasaki Hospital, Kobe, JapanDepartment of Internal Medicine, Kawasaki Hospital, Kobe, JapanDepartment of Laboratory Medicine, Kawasaki Hospital, Kobe, JapanA 77-year-old woman visited our institution complaining of general fatigue. Chest radiography revealed masses in the upper and middle lung fields. Pathological findings for an endoscopic biopsy specimen revealed squamous cell carcinoma. High-grade fever developed and blood analyses revealed sustained elevated white blood cell count and C-reactive protein levels. Cytokine production by tumor cells was suspected; both serum granulocyte colony-stimulating factor (117 pg/mL; normal: <57.5 pg/mL) and interleukin-6 (83.5 pg/mL; normal: <2.41 pg/mL) levels were high. Immunohistochemical examination of biopsy specimens showed positive staining with antigranulocyte colony-stimulating factor and anti-interleukin-6 monoclonal antibodies. Diagnosis of a tumor that produced granulocyte colony-stimulating factor and interleukin-6 was established. The patient was administered best supportive therapy since she was not eligible for surgical treatment because of her poor respiratory function. She died from interstitial pneumonia exacerbation two months after this diagnosis. We present a female with squamous cell carcinoma of the lung that produced granulocyte colony-stimulating factor and interleukin-6.http://dx.doi.org/10.1155/2013/325127 |
| spellingShingle | Nobuhiro Takeuchi Kento Yamamoto Kazuyoshi Naba A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6 Case Reports in Medicine |
| title | A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6 |
| title_full | A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6 |
| title_fullStr | A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6 |
| title_full_unstemmed | A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6 |
| title_short | A Case of Squamous Cell Carcinoma of the Lung That Produced Granulocyte Colony-Stimulating Factor and Interleukin-6 |
| title_sort | case of squamous cell carcinoma of the lung that produced granulocyte colony stimulating factor and interleukin 6 |
| url | http://dx.doi.org/10.1155/2013/325127 |
| work_keys_str_mv | AT nobuhirotakeuchi acaseofsquamouscellcarcinomaofthelungthatproducedgranulocytecolonystimulatingfactorandinterleukin6 AT kentoyamamoto acaseofsquamouscellcarcinomaofthelungthatproducedgranulocytecolonystimulatingfactorandinterleukin6 AT kazuyoshinaba acaseofsquamouscellcarcinomaofthelungthatproducedgranulocytecolonystimulatingfactorandinterleukin6 AT nobuhirotakeuchi caseofsquamouscellcarcinomaofthelungthatproducedgranulocytecolonystimulatingfactorandinterleukin6 AT kentoyamamoto caseofsquamouscellcarcinomaofthelungthatproducedgranulocytecolonystimulatingfactorandinterleukin6 AT kazuyoshinaba caseofsquamouscellcarcinomaofthelungthatproducedgranulocytecolonystimulatingfactorandinterleukin6 |