Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary
Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at...
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| Language: | English |
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Elsevier
2025-04-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328724001767 |
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| author | Camilla Lomholt Kjersgaard, MD Andreas Ernst, MD, PhD Pernille Jul Clemmensen, MD, PhD Lea Lykke Harrits Lunddorf, MD, PhD Linn Håkonsen Arendt, MD, PhD Nis Brix, MD, PhD Onyebuchi A. Arah, MD, PhD Mette Deleuran, MD, PhD Cecilia Høst Ramlau-Hansen, MHSc, PhD |
| author_facet | Camilla Lomholt Kjersgaard, MD Andreas Ernst, MD, PhD Pernille Jul Clemmensen, MD, PhD Lea Lykke Harrits Lunddorf, MD, PhD Linn Håkonsen Arendt, MD, PhD Nis Brix, MD, PhD Onyebuchi A. Arah, MD, PhD Mette Deleuran, MD, PhD Cecilia Høst Ramlau-Hansen, MHSc, PhD |
| author_sort | Camilla Lomholt Kjersgaard, MD |
| collection | DOAJ |
| description | Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model. Results: In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively. Limitations: No information on treatment was available. Missing data on covariates (<5%) were not addressed. Conclusion: No association was found between AD and puberty in either girls or boys. |
| format | Article |
| id | doaj-art-3b87cec49672419cb58fbd0381c3228c |
| institution | Kabale University |
| issn | 2666-3287 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj-art-3b87cec49672419cb58fbd0381c3228c2025-01-18T05:05:16ZengElsevierJAAD International2666-32872025-04-01192131Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule SummaryCamilla Lomholt Kjersgaard, MD0Andreas Ernst, MD, PhD1Pernille Jul Clemmensen, MD, PhD2Lea Lykke Harrits Lunddorf, MD, PhD3Linn Håkonsen Arendt, MD, PhD4Nis Brix, MD, PhD5Onyebuchi A. Arah, MD, PhD6Mette Deleuran, MD, PhD7Cecilia Høst Ramlau-Hansen, MHSc, PhD8Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Correspondence to: Camilla Lomholt Kjersgaard, MD, Department of Public Health, Research Unit for Epidemiology, Aarhus University, Bartholins Allé 2, 8000 Aarhus C, Denmark.Department of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Urology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Obstetrics and Gynecology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Clinical Genetics, Aarhus University Hospital, Aarhus, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, Denmark; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California; Department of Statistics and Data Science, UCLA, Los Angeles, California; Practical Causal Inference Lab, UCLA, Los Angeles, CaliforniaDepartment of Dermatology, Aarhus University Hospital, Aarhus, DenmarkDepartment of Public Health, Research Unit for Epidemiology, Aarhus University, Aarhus, DenmarkBackground: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model. Results: In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively. Limitations: No information on treatment was available. Missing data on covariates (<5%) were not addressed. Conclusion: No association was found between AD and puberty in either girls or boys.http://www.sciencedirect.com/science/article/pii/S2666328724001767atopic dermatitisatopycohort studyeczemaepidemiologymenarche |
| spellingShingle | Camilla Lomholt Kjersgaard, MD Andreas Ernst, MD, PhD Pernille Jul Clemmensen, MD, PhD Lea Lykke Harrits Lunddorf, MD, PhD Linn Håkonsen Arendt, MD, PhD Nis Brix, MD, PhD Onyebuchi A. Arah, MD, PhD Mette Deleuran, MD, PhD Cecilia Høst Ramlau-Hansen, MHSc, PhD Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary JAAD International atopic dermatitis atopy cohort study eczema epidemiology menarche |
| title | Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary |
| title_full | Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary |
| title_fullStr | Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary |
| title_full_unstemmed | Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary |
| title_short | Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary |
| title_sort | atopic dermatitis in childhood and pubertal development a nationwide cohort studycapsule summary |
| topic | atopic dermatitis atopy cohort study eczema epidemiology menarche |
| url | http://www.sciencedirect.com/science/article/pii/S2666328724001767 |
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