Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary

Atopic dermatitis in childhood and pubertal development: A nationwide cohort studyCapsule Summary

Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at...

Full description

Saved in:
Bibliographic Details
Main Authors: Camilla Lomholt Kjersgaard, MD, Andreas Ernst, MD, PhD, Pernille Jul Clemmensen, MD, PhD, Lea Lykke Harrits Lunddorf, MD, PhD, Linn Håkonsen Arendt, MD, PhD, Nis Brix, MD, PhD, Onyebuchi A. Arah, MD, PhD, Mette Deleuran, MD, PhD, Cecilia Høst Ramlau-Hansen, MHSc, PhD
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:JAAD International
Subjects:
atopic dermatitis
atopy
cohort study
eczema
epidemiology
menarche
Online Access:http://www.sciencedirect.com/science/article/pii/S2666328724001767
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model. Results: In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: −0.8; 0.8), and for hospital-diagnosed AD, it was −0.3 months (95% CI: −5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: −0.6; 0.9) and −0.3 months (95% CI: −3.6; 3.0), respectively. Limitations: No information on treatment was available. Missing data on covariates (<5%) were not addressed. Conclusion: No association was found between AD and puberty in either girls or boys.
ISSN:2666-3287

Similar Items