The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment

BackgroundThe insula is a critical node of the salience network responsible for initiating network switching, and its dysfunctional connections are linked to the mechanisms of mild cognitive impairment (MCI). This study aimed to explore the changes in functional connectivity (FC) of insular subregio...

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Bibliographic Details
Main Authors:	Darui Zheng, Chen Xue, Yingcai Feng, Yiming Ruan, Wenzhang Qi, Qianqian Yuan, Zonghong Li, Chaoyong Xiao
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-03-01
Series:	Frontiers in Aging Neuroscience
Subjects:	mild cognitive impairment Amyloid-beta tau protein insular subdivisions functional connectivity functional magnetic resonance imaging
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2025.1506478/full
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The abnormal accumulation of pathological proteins and compensatory functional connectivity enhancement of insula subdivisions in mild cognitive impairment

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