Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis
Objective. The aim of the present study was to compare periodontal status and antioxidant profile in unstimulated saliva of systemic sclerosis (SSc) patients with periodontitis and systemically healthy periodontitis patients. Design. Twenty patients with established diagnoses of systemic sclerosis a...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/7886272 |
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| author | Stefan I. Sredojevic Slavica Pavlov Dolijanovic Ivan Dozic Jovana Kuzmanovic Pficer Zoran Aleksic Natasa S. Nikolic-Jakoba |
| author_facet | Stefan I. Sredojevic Slavica Pavlov Dolijanovic Ivan Dozic Jovana Kuzmanovic Pficer Zoran Aleksic Natasa S. Nikolic-Jakoba |
| author_sort | Stefan I. Sredojevic |
| collection | DOAJ |
| description | Objective. The aim of the present study was to compare periodontal status and antioxidant profile in unstimulated saliva of systemic sclerosis (SSc) patients with periodontitis and systemically healthy periodontitis patients. Design. Twenty patients with established diagnoses of systemic sclerosis and periodontitis (SSc group) and 20 systemically healthy individuals with periodontitis (P group) were enrolled in the study. Clinical periodontal parameters (clinical attachment level (CAL), gingival recession (GR), periodontal probing depth (PPD), and gingival index (GI)) and concentration of uric acid (UA), superoxide dismutase (SOD), and glutathione peroxidase (GPX) in unstimulated saliva samples were assessed. Results. There were significantly higher mean values of CAL (4.8±0.21 mm versus 3.18±0.17 mm; p≤0.001) and GR (1.66±0.90 mm versus 0.46±0.54 mm; p≤0.001) in the SSc group when compared to the P group. Significantly higher level of GPX (p≤0.001) and SOD (p≤0.001) in unstimulated saliva was detected in the SSc group in comparison with the P group. The specific activity of UA did not significantly differ between the two groups (p=0.083). Conclusion. The results may indicate higher periodontal destruction and antioxidant perturbations in unstimulated saliva of SSc patients with periodontitis compared to systemically healthy periodontitis patients. |
| format | Article |
| id | doaj-art-3b7c48f186a843ab83671252ea710cbd |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3b7c48f186a843ab83671252ea710cbd2025-02-03T06:42:50ZengWileyMediators of Inflammation1466-18612023-01-01202310.1155/2023/7886272Salivary Antioxidant Profile in Patients with Systemic Sclerosis and PeriodontitisStefan I. Sredojevic0Slavica Pavlov Dolijanovic1Ivan Dozic2Jovana Kuzmanovic Pficer3Zoran Aleksic4Natasa S. Nikolic-Jakoba5Department of PeriodontologyInstitute of RheumatologyGeneral and Oral BiochemistryBiomedical Statistics and InformaticsDepartment of PeriodontologyDepartment of PeriodontologyObjective. The aim of the present study was to compare periodontal status and antioxidant profile in unstimulated saliva of systemic sclerosis (SSc) patients with periodontitis and systemically healthy periodontitis patients. Design. Twenty patients with established diagnoses of systemic sclerosis and periodontitis (SSc group) and 20 systemically healthy individuals with periodontitis (P group) were enrolled in the study. Clinical periodontal parameters (clinical attachment level (CAL), gingival recession (GR), periodontal probing depth (PPD), and gingival index (GI)) and concentration of uric acid (UA), superoxide dismutase (SOD), and glutathione peroxidase (GPX) in unstimulated saliva samples were assessed. Results. There were significantly higher mean values of CAL (4.8±0.21 mm versus 3.18±0.17 mm; p≤0.001) and GR (1.66±0.90 mm versus 0.46±0.54 mm; p≤0.001) in the SSc group when compared to the P group. Significantly higher level of GPX (p≤0.001) and SOD (p≤0.001) in unstimulated saliva was detected in the SSc group in comparison with the P group. The specific activity of UA did not significantly differ between the two groups (p=0.083). Conclusion. The results may indicate higher periodontal destruction and antioxidant perturbations in unstimulated saliva of SSc patients with periodontitis compared to systemically healthy periodontitis patients.http://dx.doi.org/10.1155/2023/7886272 |
| spellingShingle | Stefan I. Sredojevic Slavica Pavlov Dolijanovic Ivan Dozic Jovana Kuzmanovic Pficer Zoran Aleksic Natasa S. Nikolic-Jakoba Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis Mediators of Inflammation |
| title | Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis |
| title_full | Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis |
| title_fullStr | Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis |
| title_full_unstemmed | Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis |
| title_short | Salivary Antioxidant Profile in Patients with Systemic Sclerosis and Periodontitis |
| title_sort | salivary antioxidant profile in patients with systemic sclerosis and periodontitis |
| url | http://dx.doi.org/10.1155/2023/7886272 |
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