Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study
Background. Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified. This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring....
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2018/3735473 |
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| author | Tsutomu Takeda Kenshi Matsumoto Akihito Nagahara Hiroyuki Komori Yoichi Akazawa Yuta Nakagawa Kentaro Izumi Kohei Matsumoto Hiroya Ueyama Yuji Shimada Daisuke Asaoka Mariko Hojo Takashi Yao Sumio Watanabe |
| author_facet | Tsutomu Takeda Kenshi Matsumoto Akihito Nagahara Hiroyuki Komori Yoichi Akazawa Yuta Nakagawa Kentaro Izumi Kohei Matsumoto Hiroya Ueyama Yuji Shimada Daisuke Asaoka Mariko Hojo Takashi Yao Sumio Watanabe |
| author_sort | Tsutomu Takeda |
| collection | DOAJ |
| description | Background. Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified. This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring. Methods. Twenty-eight patients with 35 cT1a cancers were prospectively enrolled between December 2014 and February 2016. Pre- and post-ESD symptom score and HRM were recorded. Based on circumferential resection (CR), patients were divided into group A (n=17, <2/3 CR) or B (n=11, 2/3 CR or greater). HRM parameters evaluated were distal contractile integral (DCI), contractile front velocity (CFV), intrabolus pressure, integrated relaxation pressure, distal latency, and peristaltic breaks. Results. Symptom scores worsened after ESD in 8/11 patients in group B, and 0/17 patients in group A. There was no significant difference in any HRM parameter after ESD in the whole study group but mean DCI tended to increase (p=0.07). In group B, DCI increased significantly after ESD (p=0.04), and CFV tended to decrease after ESD (p=0.08). Conclusions. DCI tended to increase after esophageal ESD. ESD affected the symptom score and esophageal motility in cases with 2/3 CR or greater. This trial is registered with UMIN000015829. |
| format | Article |
| id | doaj-art-3b794074731245398331cd19de91e3be |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-3b794074731245398331cd19de91e3be2025-02-03T05:50:08ZengWileyGastroenterology Research and Practice1687-61211687-630X2018-01-01201810.1155/2018/37354733735473Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective StudyTsutomu Takeda0Kenshi Matsumoto1Akihito Nagahara2Hiroyuki Komori3Yoichi Akazawa4Yuta Nakagawa5Kentaro Izumi6Kohei Matsumoto7Hiroya Ueyama8Yuji Shimada9Daisuke Asaoka10Mariko Hojo11Takashi Yao12Sumio Watanabe13Department of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo Shizuoka Hospital, Shizuoka, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo Shizuoka Hospital, Shizuoka, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Human Pathology, Juntendo University School of Medicine, Tokyo, JapanDepartment of Gastroenterology, Juntendo University School of Medicine, Tokyo, JapanBackground. Endoscopic submucosal dissection (ESD) of esophageal tumors can cause stenosis, yet the effect of esophageal ESD on motility remains unclarified. This study aimed to compare esophageal motility and symptoms, before and after ESD, using high-resolution manometry (HRM) and symptom scoring. Methods. Twenty-eight patients with 35 cT1a cancers were prospectively enrolled between December 2014 and February 2016. Pre- and post-ESD symptom score and HRM were recorded. Based on circumferential resection (CR), patients were divided into group A (n=17, <2/3 CR) or B (n=11, 2/3 CR or greater). HRM parameters evaluated were distal contractile integral (DCI), contractile front velocity (CFV), intrabolus pressure, integrated relaxation pressure, distal latency, and peristaltic breaks. Results. Symptom scores worsened after ESD in 8/11 patients in group B, and 0/17 patients in group A. There was no significant difference in any HRM parameter after ESD in the whole study group but mean DCI tended to increase (p=0.07). In group B, DCI increased significantly after ESD (p=0.04), and CFV tended to decrease after ESD (p=0.08). Conclusions. DCI tended to increase after esophageal ESD. ESD affected the symptom score and esophageal motility in cases with 2/3 CR or greater. This trial is registered with UMIN000015829.http://dx.doi.org/10.1155/2018/3735473 |
| spellingShingle | Tsutomu Takeda Kenshi Matsumoto Akihito Nagahara Hiroyuki Komori Yoichi Akazawa Yuta Nakagawa Kentaro Izumi Kohei Matsumoto Hiroya Ueyama Yuji Shimada Daisuke Asaoka Mariko Hojo Takashi Yao Sumio Watanabe Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study Gastroenterology Research and Practice |
| title | Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study |
| title_full | Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study |
| title_fullStr | Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study |
| title_full_unstemmed | Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study |
| title_short | Effect of Esophageal Endoscopic Submucosal Dissection on Motility and Symptoms: A Prospective Study |
| title_sort | effect of esophageal endoscopic submucosal dissection on motility and symptoms a prospective study |
| url | http://dx.doi.org/10.1155/2018/3735473 |
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