Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening.
<h4>Background</h4>The World Health Organization (WHO) recommended cryptococcal antigen (CrAg) screening for people presenting with advanced HIV disease (AHD) and for those with positive CrAg without evidence of meningitis to initiate preemptive antifungal medication. Data on the impleme...
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Public Library of Science (PLoS)
2025-01-01
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| Online Access: | https://doi.org/10.1371/journal.pone.0313453 |
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| author | Zuhura Mbwana Ally Jackline Vicent Mbishi Mariam Salim Mbwana Hafidha Mhando Bakari Swalehe Mustafa Salim Zarin Nudar Rodoshi Muhidin Ibrahim Hundisa Rebecca Mesfin Sileshi Biruk Demisse Ayalew Rahma Musoke Lynn Moshi Yousef Elias Fakhoury Haji Mbwana Ally Habib Omari Ramadhani |
| author_facet | Zuhura Mbwana Ally Jackline Vicent Mbishi Mariam Salim Mbwana Hafidha Mhando Bakari Swalehe Mustafa Salim Zarin Nudar Rodoshi Muhidin Ibrahim Hundisa Rebecca Mesfin Sileshi Biruk Demisse Ayalew Rahma Musoke Lynn Moshi Yousef Elias Fakhoury Haji Mbwana Ally Habib Omari Ramadhani |
| author_sort | Zuhura Mbwana Ally |
| collection | DOAJ |
| description | <h4>Background</h4>The World Health Organization (WHO) recommended cryptococcal antigen (CrAg) screening for people presenting with advanced HIV disease (AHD) and for those with positive CrAg without evidence of meningitis to initiate preemptive antifungal medication. Data on the implementation of WHO recommendations regarding CrAg screening is limited. We estimated pooled prevalence of CrAg screening uptake, cryptococcal antigenemia, lumbar puncture, cryptococcal meningitis and initiation of preemptive antifungal medication from available eligible published studies conducted in Africa.<h4>Methods</h4>PubMed, Cochrane Library and Embase were searched for articles published between January 2011 and December 2023. CrAg uptake was defined as percentage of eligible people (CD4 ≤ 200 cells/mm3 or WHO stage III/IV) who received cryptococcal antigen testing. Stratified analysis to compare uptake and cryptococcal antigenemia between studies that involved multiple vs single sites was performed. Using random effects models, we computed the pooled estimate of CrAg screening uptake, cryptococcal antigenemia, lumbar puncture, cryptococcal meningitis, preemptive antifungals treatment and 95% confidence intervals (CIs).<h4>Results</h4>Ten studies with 18,820 individuals with AHD were analyzed. Overall, the pooled estimate of CrAg screening uptake was 57.1% (95% CI: 41.4-72.7). CrAg screening uptake was significantly lower among studies that involved multiple sites compared to those that involved single site, (47.3% vs 73.3%; p<0.001). Overall, the pooled prevalence of cryptococcal antigenemia was 9.6% (95% CI:6.4-12.9). Cryptococcal antigenemia was significantly lower among studies that involved multiple sites compared to those that involved single site, (9.1% vs 10.4%; p<0.001). Among those who tested positive for CrAg, 84.6% (95% CI: 54.1-99.0) received preemptive antifungal treatment, though nearly 25% did not undergo lumbar puncture, highlighting gaps in diagnostic follow-up. Six studies evaluated CrAg positive patients with lumbar puncture and the overall prevalence of lumbar puncture was 74.9% (48.0-94.8). The overall prevalence of cryptococcal meningitis was 58.1% (46.6-69.6).<h4>Conclusions</h4>Not screening for CrAg among people with AHD and failure to initiate antifungal medications among eligible patients with cryptococcal antigenemia presents a significant missed opportunity. Emphasis on improving CrAg screening is critical given its proven cost-effective benefits. |
| format | Article |
| id | doaj-art-3b6debb649c44a1dab02b48f16f8ae83 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-3b6debb649c44a1dab02b48f16f8ae832025-02-05T05:32:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031345310.1371/journal.pone.0313453Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening.Zuhura Mbwana AllyJackline Vicent MbishiMariam Salim MbwanaHafidha Mhando BakariSwalehe Mustafa SalimZarin Nudar RodoshiMuhidin Ibrahim HundisaRebecca Mesfin SileshiBiruk Demisse AyalewRahma MusokeLynn MoshiYousef Elias FakhouryHaji Mbwana AllyHabib Omari Ramadhani<h4>Background</h4>The World Health Organization (WHO) recommended cryptococcal antigen (CrAg) screening for people presenting with advanced HIV disease (AHD) and for those with positive CrAg without evidence of meningitis to initiate preemptive antifungal medication. Data on the implementation of WHO recommendations regarding CrAg screening is limited. We estimated pooled prevalence of CrAg screening uptake, cryptococcal antigenemia, lumbar puncture, cryptococcal meningitis and initiation of preemptive antifungal medication from available eligible published studies conducted in Africa.<h4>Methods</h4>PubMed, Cochrane Library and Embase were searched for articles published between January 2011 and December 2023. CrAg uptake was defined as percentage of eligible people (CD4 ≤ 200 cells/mm3 or WHO stage III/IV) who received cryptococcal antigen testing. Stratified analysis to compare uptake and cryptococcal antigenemia between studies that involved multiple vs single sites was performed. Using random effects models, we computed the pooled estimate of CrAg screening uptake, cryptococcal antigenemia, lumbar puncture, cryptococcal meningitis, preemptive antifungals treatment and 95% confidence intervals (CIs).<h4>Results</h4>Ten studies with 18,820 individuals with AHD were analyzed. Overall, the pooled estimate of CrAg screening uptake was 57.1% (95% CI: 41.4-72.7). CrAg screening uptake was significantly lower among studies that involved multiple sites compared to those that involved single site, (47.3% vs 73.3%; p<0.001). Overall, the pooled prevalence of cryptococcal antigenemia was 9.6% (95% CI:6.4-12.9). Cryptococcal antigenemia was significantly lower among studies that involved multiple sites compared to those that involved single site, (9.1% vs 10.4%; p<0.001). Among those who tested positive for CrAg, 84.6% (95% CI: 54.1-99.0) received preemptive antifungal treatment, though nearly 25% did not undergo lumbar puncture, highlighting gaps in diagnostic follow-up. Six studies evaluated CrAg positive patients with lumbar puncture and the overall prevalence of lumbar puncture was 74.9% (48.0-94.8). The overall prevalence of cryptococcal meningitis was 58.1% (46.6-69.6).<h4>Conclusions</h4>Not screening for CrAg among people with AHD and failure to initiate antifungal medications among eligible patients with cryptococcal antigenemia presents a significant missed opportunity. Emphasis on improving CrAg screening is critical given its proven cost-effective benefits.https://doi.org/10.1371/journal.pone.0313453 |
| spellingShingle | Zuhura Mbwana Ally Jackline Vicent Mbishi Mariam Salim Mbwana Hafidha Mhando Bakari Swalehe Mustafa Salim Zarin Nudar Rodoshi Muhidin Ibrahim Hundisa Rebecca Mesfin Sileshi Biruk Demisse Ayalew Rahma Musoke Lynn Moshi Yousef Elias Fakhoury Haji Mbwana Ally Habib Omari Ramadhani Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. PLoS ONE |
| title | Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. |
| title_full | Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. |
| title_fullStr | Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. |
| title_full_unstemmed | Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. |
| title_short | Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening. |
| title_sort | systematic review on the compliance of who guidelines in the management of patients with advanced hiv disease in africa the case of cryptococcal antigen screening |
| url | https://doi.org/10.1371/journal.pone.0313453 |
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