Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies
γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent ma...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/12/2/e007981.full |
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| author | Venkata Lokesh Battula Abhishek Maiti Adishwar Rao Akriti Agrawal Gautam Borthakur |
| author_facet | Venkata Lokesh Battula Abhishek Maiti Adishwar Rao Akriti Agrawal Gautam Borthakur |
| author_sort | Venkata Lokesh Battula |
| collection | DOAJ |
| description | γδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of relapse, enhanced graft-versus-leukemia effect, and decreased graft-versus-host disease in patients with AML who have higher reconstitution of γδ T cells following allogeneic hematopoietic stem cell transplantation. Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. In this review, we discuss γδ T cells’ biology, roles in cancer and AML, and mechanisms of immune escape and antileukemia effect; we also discuss recent clinical advances related to γδ T cells in the field of AML therapeutics. |
| format | Article |
| id | doaj-art-3b5dbe9d27ac462c95a83770656f106f |
| institution | Kabale University |
| issn | 2051-1426 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-3b5dbe9d27ac462c95a83770656f106f2025-02-06T00:10:10ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262024-02-0112210.1136/jitc-2023-007981Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategiesVenkata Lokesh Battula0Abhishek Maiti1Adishwar Rao2Akriti Agrawal3Gautam Borthakur4Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USADermatology, Venereology and Leprology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, IndiaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, USAγδ T cells play an important role in disease control in acute myeloid leukemia (AML) and have become an emerging area of therapeutic interest. These cells represent a minor population of T lymphocytes with intrinsic abilities to recognize antigens in a major histocompatibility complex-independent manner and functionally straddle the innate and adaptive immunity interface. AML shows high expression of phosphoantigens and UL-16 binding proteins that activate the Vδ2 and Vδ1 subtypes of γδ T cells, respectively, leading to γδ T cell-mediated cytotoxicity. Insights from murine models and clinical data in humans show improved overall survival, leukemia-free survival, reduced risk of relapse, enhanced graft-versus-leukemia effect, and decreased graft-versus-host disease in patients with AML who have higher reconstitution of γδ T cells following allogeneic hematopoietic stem cell transplantation. Clinical trials leveraging γδ T cell biology have used unmodified and modified allogeneic cells as well as bispecific engagers and monoclonal antibodies. In this review, we discuss γδ T cells’ biology, roles in cancer and AML, and mechanisms of immune escape and antileukemia effect; we also discuss recent clinical advances related to γδ T cells in the field of AML therapeutics.https://jitc.bmj.com/content/12/2/e007981.full |
| spellingShingle | Venkata Lokesh Battula Abhishek Maiti Adishwar Rao Akriti Agrawal Gautam Borthakur Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies Journal for ImmunoTherapy of Cancer |
| title | Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies |
| title_full | Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies |
| title_fullStr | Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies |
| title_full_unstemmed | Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies |
| title_short | Gamma delta T cells in acute myeloid leukemia: biology and emerging therapeutic strategies |
| title_sort | gamma delta t cells in acute myeloid leukemia biology and emerging therapeutic strategies |
| url | https://jitc.bmj.com/content/12/2/e007981.full |
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