High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods

High-level biosynthesis and purification of the antimicrobial peptide Kiadin based on non-chromatographic purification and acid cleavage methods

Abstract Antimicrobial peptides (AMPs) are renowned for their potent bacteriostatic activity and safety, rendering them invaluable in animal husbandry, food safety, and medicine. Despite their potential, the physiological toxicity of AMPs to host cells significantly hampers their biosynthetic produc...

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Bibliographic Details
Main Authors: Liangjun Zheng, Fengyi Yang, Chen Wang, Muhammad Zafir, Zishuo Gao, Pilong Liu, Fatma A. El-Gohary, Xin Zhao, Huping Xue
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Biotechnology for Biofuels and Bioproducts
Subjects:
Antimicrobial peptide
Biosynthesis
DAMP4
Acid cleavage
Non-chromatographic purification
Online Access:https://doi.org/10.1186/s13068-025-02607-8
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