Regulation of Dendritic Cell Function in Inflammation
Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surro...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/743169 |
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| _version_ | 1832545497336774656 |
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| author | André Said Günther Weindl |
| author_facet | André Said Günther Weindl |
| author_sort | André Said |
| collection | DOAJ |
| description | Dendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state. We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermatitis. Understanding the complex immunoregulatory role of distinct DC subsets in inflamed human skin will be a key element in developing novel strategies in anti-inflammatory therapy. |
| format | Article |
| id | doaj-art-3b5572a87a2f4541b19a68d1c5e07313 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-3b5572a87a2f4541b19a68d1c5e073132025-02-03T07:25:33ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/743169743169Regulation of Dendritic Cell Function in InflammationAndré Said0Günther Weindl1Institut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, 14195 Berlin, GermanyInstitut für Pharmazie (Pharmakologie und Toxikologie), Freie Universität Berlin, 14195 Berlin, GermanyDendritic cells (DC) are professional antigen presenting cells and link the innate and adaptive immune system. During steady state immune surveillance in skin, DC act as sentinels against commensals and invading pathogens. Under pathological skin conditions, inflammatory cytokines, secreted by surrounding keratinocytes, dermal fibroblasts, and immune cells, influence the activation and maturation of different DC populations including Langerhans cells (LC) and dermal DC. In this review we address critical differences in human DC subtypes during inflammatory settings compared to steady state. We also highlight the functional characteristics of human DC subsets in inflammatory skin environments and skin diseases including psoriasis and atopic dermatitis. Understanding the complex immunoregulatory role of distinct DC subsets in inflamed human skin will be a key element in developing novel strategies in anti-inflammatory therapy.http://dx.doi.org/10.1155/2015/743169 |
| spellingShingle | André Said Günther Weindl Regulation of Dendritic Cell Function in Inflammation Journal of Immunology Research |
| title | Regulation of Dendritic Cell Function in Inflammation |
| title_full | Regulation of Dendritic Cell Function in Inflammation |
| title_fullStr | Regulation of Dendritic Cell Function in Inflammation |
| title_full_unstemmed | Regulation of Dendritic Cell Function in Inflammation |
| title_short | Regulation of Dendritic Cell Function in Inflammation |
| title_sort | regulation of dendritic cell function in inflammation |
| url | http://dx.doi.org/10.1155/2015/743169 |
| work_keys_str_mv | AT andresaid regulationofdendriticcellfunctionininflammation AT guntherweindl regulationofdendriticcellfunctionininflammation |