Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients
Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of th...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/734857 |
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| author | Fernando G. Zampieri Vanessa Jacob Hermes V. Barbeiro Fabiano Pinheiro da Silva Heraldo P. de Souza |
| author_facet | Fernando G. Zampieri Vanessa Jacob Hermes V. Barbeiro Fabiano Pinheiro da Silva Heraldo P. de Souza |
| author_sort | Fernando G. Zampieri |
| collection | DOAJ |
| description | Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured. Results. We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. Higher BMI was associated with higher levels of anti-inflammatory interleukins. Conclusion. BMI may influence host response to infection during critical illness. Larger studies should confirm these findings. |
| format | Article |
| id | doaj-art-3b4c1d00f65d4fadba2e47632c93f4c0 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-3b4c1d00f65d4fadba2e47632c93f4c02025-02-03T05:59:19ZengWileyInternational Journal of Inflammation2090-80402042-00992015-01-01201510.1155/2015/734857734857Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic PatientsFernando G. Zampieri0Vanessa Jacob1Hermes V. Barbeiro2Fabiano Pinheiro da Silva3Heraldo P. de Souza4Medical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, BrazilMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, BrazilMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, BrazilMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, BrazilMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, BrazilIntroduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured. Results. We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. Higher BMI was associated with higher levels of anti-inflammatory interleukins. Conclusion. BMI may influence host response to infection during critical illness. Larger studies should confirm these findings.http://dx.doi.org/10.1155/2015/734857 |
| spellingShingle | Fernando G. Zampieri Vanessa Jacob Hermes V. Barbeiro Fabiano Pinheiro da Silva Heraldo P. de Souza Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients International Journal of Inflammation |
| title | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
| title_full | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
| title_fullStr | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
| title_full_unstemmed | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
| title_short | Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients |
| title_sort | influence of body mass index on inflammatory profile at admission in critically ill septic patients |
| url | http://dx.doi.org/10.1155/2015/734857 |
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