Materials-based hair follicle engineering: Basic components and recent advances
The hair follicle (HF) is a significant skin appendage whose primary function is to produce the hair shaft. HFs are a non-renewable resource; skin damage or follicle closure may lead to permanent hair loss. Advances in biomaterials and biomedical engineering enable the feasibility of manipulating th...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006424003648 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850110952658173952 |
|---|---|
| author | Yudie Lv Weili Yang Perumal Ramesh Kannan Han Zhang Rui Zhang Ruibo Zhao Xiangdong Kong |
| author_facet | Yudie Lv Weili Yang Perumal Ramesh Kannan Han Zhang Rui Zhang Ruibo Zhao Xiangdong Kong |
| author_sort | Yudie Lv |
| collection | DOAJ |
| description | The hair follicle (HF) is a significant skin appendage whose primary function is to produce the hair shaft. HFs are a non-renewable resource; skin damage or follicle closure may lead to permanent hair loss. Advances in biomaterials and biomedical engineering enable the feasibility of manipulating the HF-associated cell function for follicle reconstruction via rational design. The regeneration of bioengineered HF addresses the issue of limited resources and contributes to advancements in research and applications in hair loss treatment, HF development, and drug screening. Based on these requirements, this review summarizes the basic and recent advances in hair follicle regulation, including four components: acquisition of stem cells, signaling pathways, materials, and engineering methods. Recent studies have focused on efficiently combining these components and reproducing functionality, which would boost fabrication in HF rebuilding ex vivo, thereby eliminating the obstacles of transplantation into animals to promote mature development. |
| format | Article |
| id | doaj-art-3b48475faa6c4d4f9f64952dd9770c00 |
| institution | OA Journals |
| issn | 2590-0064 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-3b48475faa6c4d4f9f64952dd9770c002025-08-20T02:37:43ZengElsevierMaterials Today Bio2590-00642024-12-012910130310.1016/j.mtbio.2024.101303Materials-based hair follicle engineering: Basic components and recent advancesYudie Lv0Weili Yang1Perumal Ramesh Kannan2Han Zhang3Rui Zhang4Ruibo Zhao5Xiangdong Kong6Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaInstitute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaInstitute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaInstitute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaInstitute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, ChinaInstitute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Corresponding author. Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Zhejiang-Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou, 310018, China; Corresponding author. Institute of Smart Biomedical Materials, School of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China.The hair follicle (HF) is a significant skin appendage whose primary function is to produce the hair shaft. HFs are a non-renewable resource; skin damage or follicle closure may lead to permanent hair loss. Advances in biomaterials and biomedical engineering enable the feasibility of manipulating the HF-associated cell function for follicle reconstruction via rational design. The regeneration of bioengineered HF addresses the issue of limited resources and contributes to advancements in research and applications in hair loss treatment, HF development, and drug screening. Based on these requirements, this review summarizes the basic and recent advances in hair follicle regulation, including four components: acquisition of stem cells, signaling pathways, materials, and engineering methods. Recent studies have focused on efficiently combining these components and reproducing functionality, which would boost fabrication in HF rebuilding ex vivo, thereby eliminating the obstacles of transplantation into animals to promote mature development.http://www.sciencedirect.com/science/article/pii/S2590006424003648Hair follicleStem cellsSignaling pathwaysMaterialsEngineering methods |
| spellingShingle | Yudie Lv Weili Yang Perumal Ramesh Kannan Han Zhang Rui Zhang Ruibo Zhao Xiangdong Kong Materials-based hair follicle engineering: Basic components and recent advances Materials Today Bio Hair follicle Stem cells Signaling pathways Materials Engineering methods |
| title | Materials-based hair follicle engineering: Basic components and recent advances |
| title_full | Materials-based hair follicle engineering: Basic components and recent advances |
| title_fullStr | Materials-based hair follicle engineering: Basic components and recent advances |
| title_full_unstemmed | Materials-based hair follicle engineering: Basic components and recent advances |
| title_short | Materials-based hair follicle engineering: Basic components and recent advances |
| title_sort | materials based hair follicle engineering basic components and recent advances |
| topic | Hair follicle Stem cells Signaling pathways Materials Engineering methods |
| url | http://www.sciencedirect.com/science/article/pii/S2590006424003648 |
| work_keys_str_mv | AT yudielv materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances AT weiliyang materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances AT perumalrameshkannan materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances AT hanzhang materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances AT ruizhang materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances AT ruibozhao materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances AT xiangdongkong materialsbasedhairfollicleengineeringbasiccomponentsandrecentadvances |