Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults
Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascula...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/181054 |
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| author | Luc Djoussé Marlena Maziarz Mary L. Biggs Joachim H. Ix Susan J. Zieman Jorge R. Kizer Rozenn N. Lemaitre Dariush Mozaffarian Russell P. Tracy Kenneth J. Mukamal David S. Siscovick Nona Sotoodehnia |
| author_facet | Luc Djoussé Marlena Maziarz Mary L. Biggs Joachim H. Ix Susan J. Zieman Jorge R. Kizer Rozenn N. Lemaitre Dariush Mozaffarian Russell P. Tracy Kenneth J. Mukamal David S. Siscovick Nona Sotoodehnia |
| author_sort | Luc Djoussé |
| collection | DOAJ |
| description | Although fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through review of medical records. We used Cox proportional hazards to estimate effect measures. During a median followup of 11.8 years, 146 SCD cases occurred. In a multivariable model adjusting for demographic, lifestyle, and metabolic factors, relative risk of SCD associated with each higher standard deviation (SD) of plasma FABP4 was 1.15 (95% CI: 0.95–1.38), P=0.15. In a secondary analysis stratified by prevalent diabetes status, FABP4 was associated with higher risk of SCD in nondiabetic participants, (RR per SD higher FABP4: 1.33 (95% CI: 1.07–1.65), P=0.009) but not in diabetic participants (RR per SD higher FABP4: 0.88 (95% CI: 0.62–1.27), P=0.50), P for diabetes-FABP4 interaction 0.049. In summary, a single measure of plasma FABP4 obtained later in life was not associated with the risk of SCD in older adults overall. Confirmation of our post-hoc results in nondiabetic people in other studies is warranted. |
| format | Article |
| id | doaj-art-3b2510f83da64a0796b2baade446bcfa |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-3b2510f83da64a0796b2baade446bcfa2025-08-20T02:08:03ZengWileyCardiology Research and Practice2090-80162090-05972013-01-01201310.1155/2013/181054181054Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older AdultsLuc Djoussé0Marlena Maziarz1Mary L. Biggs2Joachim H. Ix3Susan J. Zieman4Jorge R. Kizer5Rozenn N. Lemaitre6Dariush Mozaffarian7Russell P. Tracy8Kenneth J. Mukamal9David S. Siscovick10Nona Sotoodehnia11Division of Aging, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, 1620 Tremont Street, 3rd Floor, Boston, MA 02120, USADepartment of Biostatistics, University of Washington, Seattle, WA 98195, USADepartment of Biostatistics, University of Washington, Seattle, WA 98195, USANephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, CA 92161, USANational Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USACardiology Division, Albert Einstein College of Medicine, New York, NY 10461, USACardiovascular Health Research Unit, Departments of Medicine, University of Washington, Seattle, WA 98195, USADepartment of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02120, USADepartment of Pathology and Biochemistry, University of Vermont College of Medicine, Burlington, VT 05401, USADivision of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02120, USACardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98195, USACardiovascular Health Research Unit, Departments of Medicine and Epidemiology, University of Washington, Seattle, WA 98195, USAAlthough fatty acid binding protein 4 (FABP4) may increase risk of diabetes and exert negative cardiac inotropy, it is unknown whether plasma concentrations of FABP4 are associated with incidence of sudden cardiac death (SCD). We prospectively analyzed data on 4,560 participants of the Cardiovascular Health Study. FABP4 was measured at baseline using ELISA, and SCD events were adjudicated through review of medical records. We used Cox proportional hazards to estimate effect measures. During a median followup of 11.8 years, 146 SCD cases occurred. In a multivariable model adjusting for demographic, lifestyle, and metabolic factors, relative risk of SCD associated with each higher standard deviation (SD) of plasma FABP4 was 1.15 (95% CI: 0.95–1.38), P=0.15. In a secondary analysis stratified by prevalent diabetes status, FABP4 was associated with higher risk of SCD in nondiabetic participants, (RR per SD higher FABP4: 1.33 (95% CI: 1.07–1.65), P=0.009) but not in diabetic participants (RR per SD higher FABP4: 0.88 (95% CI: 0.62–1.27), P=0.50), P for diabetes-FABP4 interaction 0.049. In summary, a single measure of plasma FABP4 obtained later in life was not associated with the risk of SCD in older adults overall. Confirmation of our post-hoc results in nondiabetic people in other studies is warranted.http://dx.doi.org/10.1155/2013/181054 |
| spellingShingle | Luc Djoussé Marlena Maziarz Mary L. Biggs Joachim H. Ix Susan J. Zieman Jorge R. Kizer Rozenn N. Lemaitre Dariush Mozaffarian Russell P. Tracy Kenneth J. Mukamal David S. Siscovick Nona Sotoodehnia Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults Cardiology Research and Practice |
| title | Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults |
| title_full | Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults |
| title_fullStr | Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults |
| title_full_unstemmed | Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults |
| title_short | Plasma Fatty Acid Binding Protein 4 and Risk of Sudden Cardiac Death in Older Adults |
| title_sort | plasma fatty acid binding protein 4 and risk of sudden cardiac death in older adults |
| url | http://dx.doi.org/10.1155/2013/181054 |
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