White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review.
<h4>Background</h4>Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic review to identify the specific white matter lesions and DTI metrics strongly a...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0312378 |
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| author | Yu Jiang Gang Liu Bowen Deng Xiaoye Li Jingpei Ren Yi Zhao Chuanyu Hu Lin Xu Feng Gao Xiaohong Mu |
| author_facet | Yu Jiang Gang Liu Bowen Deng Xiaoye Li Jingpei Ren Yi Zhao Chuanyu Hu Lin Xu Feng Gao Xiaohong Mu |
| author_sort | Yu Jiang |
| collection | DOAJ |
| description | <h4>Background</h4>Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic review to identify the specific white matter lesions and DTI metrics strongly associated with various types of dysfunction in cerebral palsy.<h4>Methods</h4>We conducted a literature search of PubMed, Embase, Cochrane Library and Web of Science databases to identify trials published that had evaluated the correlation between DTI metrics in sensorimotor pathways and function scores in cerebral palsy. Correlation coefficient (r) values were extracted for each study, and the extent of r was quantitatively explored. The remaining part of the study was analyzed qualitatively.<h4>Results</h4>46 studies involving 1458 children with cerebral palsy, were included. 19 articles for Meta-analysis and 27 articles were descriptively analyzed. DTI metrics such as FA、MD in both sensory and motor pathways significantly correlated with various function ratings. In overall motor dysfunction, compared with the CST and PTR, FA of the PLIC correlated more strongly with GMFCS, and showed no significant heterogeneity (r = -1.28, confidence interval [CI]-1.70 to -0.87,I2 = 38.2%,P = 0.233). In upper limb dysfunction, compared with the AHA and MA2, FA of the CST correlated more strongly with BBT, and showed no significant heterogeneity (r = -0.56, confidence interval [CI]-0.78 to -0.34,I2 = 0.0%,P = 0.511). Lower limb dysfunction and other dysfunctions we used qualitative analysis. The qualitative analysis offered a concise overview of each investigation.<h4>Conclusions</h4>This study basically identifies the specific white matter lesions corresponding to overall motor dysfunction, upper limb and lower limb motor deficits and other dysfunctions in patients with cerebral palsy, as well as the associated DTI metrics. |
| format | Article |
| id | doaj-art-3b1426485c414f7d88dd57f1508863bf |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-3b1426485c414f7d88dd57f1508863bf2025-02-05T05:32:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01201e031237810.1371/journal.pone.0312378White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review.Yu JiangGang LiuBowen DengXiaoye LiJingpei RenYi ZhaoChuanyu HuLin XuFeng GaoXiaohong Mu<h4>Background</h4>Assessing various types of dysfunction in cerebral palsy is a key factor in the treatment and rehabilitation of patients. The objective of this study was to use meta-analysis and systematic review to identify the specific white matter lesions and DTI metrics strongly associated with various types of dysfunction in cerebral palsy.<h4>Methods</h4>We conducted a literature search of PubMed, Embase, Cochrane Library and Web of Science databases to identify trials published that had evaluated the correlation between DTI metrics in sensorimotor pathways and function scores in cerebral palsy. Correlation coefficient (r) values were extracted for each study, and the extent of r was quantitatively explored. The remaining part of the study was analyzed qualitatively.<h4>Results</h4>46 studies involving 1458 children with cerebral palsy, were included. 19 articles for Meta-analysis and 27 articles were descriptively analyzed. DTI metrics such as FA、MD in both sensory and motor pathways significantly correlated with various function ratings. In overall motor dysfunction, compared with the CST and PTR, FA of the PLIC correlated more strongly with GMFCS, and showed no significant heterogeneity (r = -1.28, confidence interval [CI]-1.70 to -0.87,I2 = 38.2%,P = 0.233). In upper limb dysfunction, compared with the AHA and MA2, FA of the CST correlated more strongly with BBT, and showed no significant heterogeneity (r = -0.56, confidence interval [CI]-0.78 to -0.34,I2 = 0.0%,P = 0.511). Lower limb dysfunction and other dysfunctions we used qualitative analysis. The qualitative analysis offered a concise overview of each investigation.<h4>Conclusions</h4>This study basically identifies the specific white matter lesions corresponding to overall motor dysfunction, upper limb and lower limb motor deficits and other dysfunctions in patients with cerebral palsy, as well as the associated DTI metrics.https://doi.org/10.1371/journal.pone.0312378 |
| spellingShingle | Yu Jiang Gang Liu Bowen Deng Xiaoye Li Jingpei Ren Yi Zhao Chuanyu Hu Lin Xu Feng Gao Xiaohong Mu White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review. PLoS ONE |
| title | White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review. |
| title_full | White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review. |
| title_fullStr | White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review. |
| title_full_unstemmed | White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review. |
| title_short | White matter lesions and DTI metrics related to various types of dysfunction in cerebral palsy: A meta-analysis and systematic review. |
| title_sort | white matter lesions and dti metrics related to various types of dysfunction in cerebral palsy a meta analysis and systematic review |
| url | https://doi.org/10.1371/journal.pone.0312378 |
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