First molecules to reactivate RASG12V GTPase activity

First molecules to reactivate RASG12V GTPase activity

Abstract Background Small-molecule compounds that even partially restore the GTPase activity of RASG12V can be used in anticancer therapy. Until now, attempts to obtain such compounds have failed. Compounds with this ability have been defined in our research. Methods The compounds were initially ide...

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Bibliographic Details
Main Authors: Aneta Wlodarczyk, Cezary Treda, Marcin Pacholczyk, Adrianna Rutkowska, Marta Wegierska, Amelia Kierasinska-Kalka, Katarzyna Wasiak, Damian Ciunowicz, Dagmara Grot, Pawel Glowacki, Ewelina Stoczynska-Fidelus, Piotr Rieske
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Cancer
Subjects:
RAS
Small molecule
GTPase
Lung cancer
Colorectal cancer
Pancreatic cancer
Online Access:https://doi.org/10.1186/s12885-025-13580-8
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