Potent neutralising monoclonal antibodies targeting the spike of NL63 coronavirus

Potent neutralising monoclonal antibodies targeting the spike of NL63 coronavirus

Abstract NL63 is an alphacoronavirus that uses the same ACE2 receptor as SARS-CoV and SARS-CoV-2, but generally causes mild respiratory illness. In a cohort of healthy adults, we characterised humoral responses against NL63 spike and isolated a panel of human monoclonal antibodies (mAbs), including...

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Main Authors: Wen Shi Lee, George Taiaroa, Robyn Esterbauer, Meghan Conlan, Jessica A. Neil, Matthew J. Gartner, Monique Smith, Mingyang Wang, Rory A. Shepherd, Thomas Tran, Phillip Pymm, Lara S. U. Schwab, Andrew Kelly, Ellie Reilly, Thakshila Amarasena, Bruce D. Wines, P. Mark Hogarth, Jennifer A. Juno, Stephen J. Kent, Hyon-Xhi Tan, Kanta Subbarao, Adam K. Wheatley
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Viruses
Online Access:https://doi.org/10.1038/s44298-025-00116-x
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