PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease

PPM1M, an LRRK2-counteracting, phosphoRab12-preferring phosphatase with a potential link to Parkinson’s disease

Summary: Leucine-rich repeat kinase 2 (LRRK2) phosphorylates a subset of Rab GTPases that regulate receptor trafficking, and LRRK2-activating mutations are linked to Parkinson’s disease. Rab phosphorylation is a transient event that can be reversed by phosphatases, including protein phosphatase, Mg2...

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Main Authors: Claire Y. Chiang, Neringa Pratuseviciute, Yu-En Lin, Ayan Adhikari, Wondwossen M. Yeshaw, Chloe Flitton, Pemba L. Sherpa, Francesca Tonelli, Irena Rektorova, Timothy Lynch, Joanna Siuda, Monika Rudzińska-Bar, Oleksandr Pulyk, Peter Bauer, Christian Beetz, Dennis W. Dickson, Owen A. Ross, Zbigniew K. Wszolek, Zih-Hua Fang, Christine Klein, Alexander Zimprich, Dario R. Alessi, Esther M. Sammler, Suzanne R. Pfeffer
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Cell biology
CP: Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725008022
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