Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children
Background. Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled...
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/31919 |
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| author | A. Bodini D. G. Peroni F. Zardini M. Corradi R. Alinovi A. L. Boner G. L. Piacentini |
| author_facet | A. Bodini D. G. Peroni F. Zardini M. Corradi R. Alinovi A. L. Boner G. L. Piacentini |
| author_sort | A. Bodini |
| collection | DOAJ |
| description | Background. Exhaled nitric oxide (FeNO) has been
reported to be elevated in the oxidative stress involved in
asthmatic patients, and the reaction of nitric oxide (NO)
with superoxide anions results in the formation of nitrotyrosine.
The purpose of this study was to investigate the effect of inhaled
steroid treatment on nitrotyrosine levels collected by exhaled
breath condensate (EBC) and on FeNO. Methods. This
was a single-blind placebo-controlled study. The lung function,
FeNO, and nitrotyrosine levels were evaluated in 10
asthmatic children. Results. The nitrotyrosine levels
were stable during the placebo period (T0 = 1.16 ng/ml
versus T1 = 1.05 ng/ml; NS.), whereas they decreased
after the treatment with flunisolide (T2 = 1.14 ng/ml
versus T3 = 0.88 ng/ml; P<.001). No significant reduction in FeNO levels was observed after placebo
treatment (T0 = 38.4 ppb versus T1 = 34.7 ppb, NS.). In contrast, FeNO values
decreased significantly being at T3 = 14.9 ppb (T1
versus T3; P=.024). Conclusions. This study shows
that corticosteroid treatment reduces nitrotyrosine levels in EBC
of asthmatic subjects. |
| format | Article |
| id | doaj-art-3b05ec52ce7145e490ac61042cf685c2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3b05ec52ce7145e490ac61042cf685c22025-02-03T06:11:11ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/3191931919Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic ChildrenA. Bodini0D. G. Peroni1F. Zardini2M. Corradi3R. Alinovi4A. L. Boner5G. L. Piacentini6Department of Paediatrics, University of Verona, Verona 37134, ItalyDepartment of Paediatrics, University of Verona, Verona 37134, ItalyDepartment of Paediatrics, University of Verona, Verona 37134, ItalyLaboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma 43100, ItalyLaboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Parma 43100, ItalyDepartment of Paediatrics, University of Verona, Verona 37134, ItalyDepartment of Paediatrics, University of Verona, Verona 37134, ItalyBackground. Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled steroid treatment on nitrotyrosine levels collected by exhaled breath condensate (EBC) and on FeNO. Methods. This was a single-blind placebo-controlled study. The lung function, FeNO, and nitrotyrosine levels were evaluated in 10 asthmatic children. Results. The nitrotyrosine levels were stable during the placebo period (T0 = 1.16 ng/ml versus T1 = 1.05 ng/ml; NS.), whereas they decreased after the treatment with flunisolide (T2 = 1.14 ng/ml versus T3 = 0.88 ng/ml; P<.001). No significant reduction in FeNO levels was observed after placebo treatment (T0 = 38.4 ppb versus T1 = 34.7 ppb, NS.). In contrast, FeNO values decreased significantly being at T3 = 14.9 ppb (T1 versus T3; P=.024). Conclusions. This study shows that corticosteroid treatment reduces nitrotyrosine levels in EBC of asthmatic subjects.http://dx.doi.org/10.1155/MI/2006/31919 |
| spellingShingle | A. Bodini D. G. Peroni F. Zardini M. Corradi R. Alinovi A. L. Boner G. L. Piacentini Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children Mediators of Inflammation |
| title | Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children |
| title_full | Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children |
| title_fullStr | Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children |
| title_full_unstemmed | Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children |
| title_short | Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children |
| title_sort | flunisolide decreases exhaled nitric oxide and nitrotyrosine levels in asthmatic children |
| url | http://dx.doi.org/10.1155/MI/2006/31919 |
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