Flunisolide Decreases Exhaled Nitric Oxide and Nitrotyrosine Levels in Asthmatic Children
Background. Exhaled nitric oxide (FeNO) has been reported to be elevated in the oxidative stress involved in asthmatic patients, and the reaction of nitric oxide (NO) with superoxide anions results in the formation of nitrotyrosine. The purpose of this study was to investigate the effect of inhaled...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/31919 |
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| Summary: | Background. Exhaled nitric oxide (FeNO) has been
reported to be elevated in the oxidative stress involved in
asthmatic patients, and the reaction of nitric oxide (NO)
with superoxide anions results in the formation of nitrotyrosine.
The purpose of this study was to investigate the effect of inhaled
steroid treatment on nitrotyrosine levels collected by exhaled
breath condensate (EBC) and on FeNO. Methods. This
was a single-blind placebo-controlled study. The lung function,
FeNO, and nitrotyrosine levels were evaluated in 10
asthmatic children. Results. The nitrotyrosine levels
were stable during the placebo period (T0 = 1.16 ng/ml
versus T1 = 1.05 ng/ml; NS.), whereas they decreased
after the treatment with flunisolide (T2 = 1.14 ng/ml
versus T3 = 0.88 ng/ml; P<.001). No significant reduction in FeNO levels was observed after placebo
treatment (T0 = 38.4 ppb versus T1 = 34.7 ppb, NS.). In contrast, FeNO values
decreased significantly being at T3 = 14.9 ppb (T1
versus T3; P=.024). Conclusions. This study shows
that corticosteroid treatment reduces nitrotyrosine levels in EBC
of asthmatic subjects. |
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| ISSN: | 0962-9351 1466-1861 |