The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties
As an incretin hormone, Glucagon-like peptide-1 (GLP-1) has obvious effects on blood glucose regulation and weight loss. GLP-1 receptor (GLP-1R) agonists are synthetic products that have similar effects to GLP-1 but are less prone to degradation, and they are widely used in the treatment of type 2 d...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/61/1/17 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587986549604352 |
|---|---|
| author | Chenqi Lu Cong Xu Jun Yang |
| author_facet | Chenqi Lu Cong Xu Jun Yang |
| author_sort | Chenqi Lu |
| collection | DOAJ |
| description | As an incretin hormone, Glucagon-like peptide-1 (GLP-1) has obvious effects on blood glucose regulation and weight loss. GLP-1 receptor (GLP-1R) agonists are synthetic products that have similar effects to GLP-1 but are less prone to degradation, and they are widely used in the treatment of type 2 diabetes and obesity. In recent years, different beneficial effects of GLP-1R agonists were discovered, such as reducing ischemia-reperfusion injury, improving the function of various organs, alleviating substance use disorder, affecting tumorigenesis, regulating bone metabolism, changing gut microbiota composition, and prolonging graft survival. Therefore, GLP-1R agonists have great potential for clinical application in various diseases. Here, we briefly summarized the beneficial effects of GLP-1R agonists other than the anti-diabetic and anti-obesity effects. |
| format | Article |
| id | doaj-art-3afcbf06bf3747b78a06b75756c0dd74 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-3afcbf06bf3747b78a06b75756c0dd742025-01-24T13:40:15ZengMDPI AGMedicina1010-660X1648-91442024-12-016111710.3390/medicina61010017The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity PropertiesChenqi Lu0Cong Xu1Jun Yang2Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, ChinaDivision of Nephrology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, ChinaInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan 430030, ChinaAs an incretin hormone, Glucagon-like peptide-1 (GLP-1) has obvious effects on blood glucose regulation and weight loss. GLP-1 receptor (GLP-1R) agonists are synthetic products that have similar effects to GLP-1 but are less prone to degradation, and they are widely used in the treatment of type 2 diabetes and obesity. In recent years, different beneficial effects of GLP-1R agonists were discovered, such as reducing ischemia-reperfusion injury, improving the function of various organs, alleviating substance use disorder, affecting tumorigenesis, regulating bone metabolism, changing gut microbiota composition, and prolonging graft survival. Therefore, GLP-1R agonists have great potential for clinical application in various diseases. Here, we briefly summarized the beneficial effects of GLP-1R agonists other than the anti-diabetic and anti-obesity effects.https://www.mdpi.com/1648-9144/61/1/17GLP-1GLP-1 receptor agonistsneuroprotectioncardiovascular protectionliver protectionkidney protection |
| spellingShingle | Chenqi Lu Cong Xu Jun Yang The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties Medicina GLP-1 GLP-1 receptor agonists neuroprotection cardiovascular protection liver protection kidney protection |
| title | The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties |
| title_full | The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties |
| title_fullStr | The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties |
| title_full_unstemmed | The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties |
| title_short | The Beneficial Effects of GLP-1 Receptor Agonists Other than Their Anti-Diabetic and Anti-Obesity Properties |
| title_sort | beneficial effects of glp 1 receptor agonists other than their anti diabetic and anti obesity properties |
| topic | GLP-1 GLP-1 receptor agonists neuroprotection cardiovascular protection liver protection kidney protection |
| url | https://www.mdpi.com/1648-9144/61/1/17 |
| work_keys_str_mv | AT chenqilu thebeneficialeffectsofglp1receptoragonistsotherthantheirantidiabeticandantiobesityproperties AT congxu thebeneficialeffectsofglp1receptoragonistsotherthantheirantidiabeticandantiobesityproperties AT junyang thebeneficialeffectsofglp1receptoragonistsotherthantheirantidiabeticandantiobesityproperties AT chenqilu beneficialeffectsofglp1receptoragonistsotherthantheirantidiabeticandantiobesityproperties AT congxu beneficialeffectsofglp1receptoragonistsotherthantheirantidiabeticandantiobesityproperties AT junyang beneficialeffectsofglp1receptoragonistsotherthantheirantidiabeticandantiobesityproperties |