Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma
Squamous cell carcinoma (oral SCC) is the most common oral cancer in the U.S., affecting nearly 30,000 Americans each year. Despite recent advances in detection and treatment, there has been little improvement in the five-year survival rate for this devastating disease. Oral cancer may be preceded b...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/649731 |
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| author | Nagamani Narayana Julie Gist Tyler Smith Daniel Tylka Gavin Trogdon James K. Wahl |
| author_facet | Nagamani Narayana Julie Gist Tyler Smith Daniel Tylka Gavin Trogdon James K. Wahl |
| author_sort | Nagamani Narayana |
| collection | DOAJ |
| description | Squamous cell carcinoma (oral SCC) is the most common oral cancer in the U.S., affecting nearly 30,000 Americans each year. Despite recent advances in detection and treatment, there has been little improvement in the five-year survival rate for this devastating disease. Oral cancer may be preceded by premalignant disease that appears histologically as dysplasia. Identification of molecular markers for cellular change would assist in determining the risk of dysplasia progressing to oral squamous cell carcinoma. The goal of this study was to determine if any correlation exists between histological diagnosed dysplasia and OSCC lesions and altered expression of desmosomal cell-cell adhesion molecules in the oral epithelium. Our data showed that oral SCC tissue samples showed decreased immunoreactivity of both desmoplakin and plakophilin-1 proteins compared to normal oral epithelium. Furthermore, significant decrease in desmoplakin immunoreactivity was observed in dysplastic tissue compared to normal oral epithelium. In contrast, the level of desmoglein-1 staining was unchanged between samples however desmoglein-1 was found localized to cell borders in oral SCC samples. These data suggest that changes in expression of desmoplakin and plakophilin-1 may prove to be a useful marker for changes in tissue morphology and provide a tool for identifying pre-neoplastic lesions of the oral cavity. |
| format | Article |
| id | doaj-art-3af5a40275094903bc3698eb96b20222 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
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| series | Dermatology Research and Practice |
| spelling | doaj-art-3af5a40275094903bc3698eb96b202222025-02-03T01:12:37ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/649731649731Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell CarcinomaNagamani Narayana0Julie Gist1Tyler Smith2Daniel Tylka3Gavin Trogdon4James K. Wahl5Department of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USADepartment of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USADepartment of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USADepartment of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USADepartment of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USADepartment of Oral Biology, University of Nebraska Medical Center College of Dentistry, 40th and Holdrege, Lincoln, NE 68583, USASquamous cell carcinoma (oral SCC) is the most common oral cancer in the U.S., affecting nearly 30,000 Americans each year. Despite recent advances in detection and treatment, there has been little improvement in the five-year survival rate for this devastating disease. Oral cancer may be preceded by premalignant disease that appears histologically as dysplasia. Identification of molecular markers for cellular change would assist in determining the risk of dysplasia progressing to oral squamous cell carcinoma. The goal of this study was to determine if any correlation exists between histological diagnosed dysplasia and OSCC lesions and altered expression of desmosomal cell-cell adhesion molecules in the oral epithelium. Our data showed that oral SCC tissue samples showed decreased immunoreactivity of both desmoplakin and plakophilin-1 proteins compared to normal oral epithelium. Furthermore, significant decrease in desmoplakin immunoreactivity was observed in dysplastic tissue compared to normal oral epithelium. In contrast, the level of desmoglein-1 staining was unchanged between samples however desmoglein-1 was found localized to cell borders in oral SCC samples. These data suggest that changes in expression of desmoplakin and plakophilin-1 may prove to be a useful marker for changes in tissue morphology and provide a tool for identifying pre-neoplastic lesions of the oral cavity.http://dx.doi.org/10.1155/2010/649731 |
| spellingShingle | Nagamani Narayana Julie Gist Tyler Smith Daniel Tylka Gavin Trogdon James K. Wahl Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma Dermatology Research and Practice |
| title | Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma |
| title_full | Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma |
| title_fullStr | Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma |
| title_full_unstemmed | Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma |
| title_short | Desmosomal Component Expression in Normal, Dysplastic, and Oral Squamous Cell Carcinoma |
| title_sort | desmosomal component expression in normal dysplastic and oral squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2010/649731 |
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