Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks
Abstract α-Ketoglutaric acid (KGA) and methanetriacetic acid (MTA) are important multi-functional carboxylic acids with versatile applications. However, their synthetic processes are still not green and efficient. Herein, we report a novel one-pot approach for sustainable synthesis of KGA and MTA fr...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-025-56536-z |
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| author | Cheng-Bin Hong Wangde Hua Lieke Liu Haichao Liu |
| author_facet | Cheng-Bin Hong Wangde Hua Lieke Liu Haichao Liu |
| author_sort | Cheng-Bin Hong |
| collection | DOAJ |
| description | Abstract α-Ketoglutaric acid (KGA) and methanetriacetic acid (MTA) are important multi-functional carboxylic acids with versatile applications. However, their synthetic processes are still not green and efficient. Herein, we report a novel one-pot approach for sustainable synthesis of KGA and MTA from biomass-derived pyruvic and glyoxylic acids under mild conditions. KGA is synthesized via cross-aldol condensation of pyruvic and glyoxylic acids to 2-hydroxy-4-oxopentanedioic acid, followed by its sequential dehydration and hydrogenation on Pd/TiO2, affording a high yield of 85.4% on a molar basis of glyoxylic acid at 110 °C and 1.0 MPa H2. The synthesis of MTA involves cross-aldol condensation of KGA and glyoxylic acid to 3-(carboxymethyl)-2-hydroxy-4-oxopentanedioic acid and its subsequent hydrodeoxygenation on Pd/TiO2 and MoOx/TiO2 in a high yield of 86.2% at 200 °C and 2.0 MPa H2. This novel approach provides a rationale for the sustainable production of various multi-functional carboxylic acids that are still not easily available. |
| format | Article |
| id | doaj-art-3af587b14f45481fa609e88cc9de403e |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-3af587b14f45481fa609e88cc9de403e2025-02-02T12:32:04ZengNature PortfolioNature Communications2041-17232025-02-011611810.1038/s41467-025-56536-zSustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocksCheng-Bin Hong0Wangde Hua1Lieke Liu2Haichao Liu3Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking UniversityBeijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking UniversityAbstract α-Ketoglutaric acid (KGA) and methanetriacetic acid (MTA) are important multi-functional carboxylic acids with versatile applications. However, their synthetic processes are still not green and efficient. Herein, we report a novel one-pot approach for sustainable synthesis of KGA and MTA from biomass-derived pyruvic and glyoxylic acids under mild conditions. KGA is synthesized via cross-aldol condensation of pyruvic and glyoxylic acids to 2-hydroxy-4-oxopentanedioic acid, followed by its sequential dehydration and hydrogenation on Pd/TiO2, affording a high yield of 85.4% on a molar basis of glyoxylic acid at 110 °C and 1.0 MPa H2. The synthesis of MTA involves cross-aldol condensation of KGA and glyoxylic acid to 3-(carboxymethyl)-2-hydroxy-4-oxopentanedioic acid and its subsequent hydrodeoxygenation on Pd/TiO2 and MoOx/TiO2 in a high yield of 86.2% at 200 °C and 2.0 MPa H2. This novel approach provides a rationale for the sustainable production of various multi-functional carboxylic acids that are still not easily available.https://doi.org/10.1038/s41467-025-56536-z |
| spellingShingle | Cheng-Bin Hong Wangde Hua Lieke Liu Haichao Liu Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks Nature Communications |
| title | Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks |
| title_full | Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks |
| title_fullStr | Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks |
| title_full_unstemmed | Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks |
| title_short | Sustainable synthesis of α-ketoglutaric and methanetriacetic acids from biomass feedstocks |
| title_sort | sustainable synthesis of α ketoglutaric and methanetriacetic acids from biomass feedstocks |
| url | https://doi.org/10.1038/s41467-025-56536-z |
| work_keys_str_mv | AT chengbinhong sustainablesynthesisofaketoglutaricandmethanetriaceticacidsfrombiomassfeedstocks AT wangdehua sustainablesynthesisofaketoglutaricandmethanetriaceticacidsfrombiomassfeedstocks AT liekeliu sustainablesynthesisofaketoglutaricandmethanetriaceticacidsfrombiomassfeedstocks AT haichaoliu sustainablesynthesisofaketoglutaricandmethanetriaceticacidsfrombiomassfeedstocks |