DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer
DNA methylation is an epigenetic mark involving the addition of a methyl group to DNA, particularly at cytosine residues. This methylation plays an important role in regulating gene expression through direct gene repression or through the control of other epigenetic modifications such as histone mo...
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| Format: | Article |
| Language: | English |
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HH Publisher
2025-01-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/1102 |
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| author | Nasreddine El Omari Saad Bakrim Mohamed Bakha Abdelaali Balahbib Abdelhakim Bouyahya Chrismawan Ardianto Long Chiau Ming Hooi Leng Ser |
| author_facet | Nasreddine El Omari Saad Bakrim Mohamed Bakha Abdelaali Balahbib Abdelhakim Bouyahya Chrismawan Ardianto Long Chiau Ming Hooi Leng Ser |
| author_sort | Nasreddine El Omari |
| collection | DOAJ |
| description |
DNA methylation is an epigenetic mark involving the addition of a methyl group to DNA, particularly at cytosine residues. This methylation plays an important role in regulating gene expression through direct gene repression or through the control of other epigenetic modifications such as histone modification or chromatin remodeling. DNA methylation is catalyzed by de novo and maintenance DNMT methyltransferase type enzymes and requires the transfer of a methyl group to cytosine to transform it into 5-methyl-cytosine. Currently, several investigations have highlighted the involvement of aberrant DNA methylation with certain tumors. Indeed, the methylation of antioncogenes and/or the demethylation of oncogenes are the major alterations that are strongly linked to human cancers. DNMTs play a central role in the epigenetic regulation of the human genome, both in normal and pathological processes. Recent discoveries on the differentiated roles of DNMTs in DNA methylation, and their implication in various cancers, open the way to new therapeutic approaches targeting these enzymes to treat epigenetic diseases. It is essential to continue exploring the roles of DNMTs to better understand their implication in tumorigenesis mechanisms and to develop more effective treatment strategies.
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| format | Article |
| id | doaj-art-3aefe09f16af4a63a32930a8aae76f68 |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-3aefe09f16af4a63a32930a8aae76f682025-02-05T05:10:23ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492025-01-0181DNA Methylation: Its Role and Interaction with Epigenetic Modifications in CancerNasreddine El OmariSaad BakrimMohamed BakhaAbdelaali BalahbibAbdelhakim BouyahyaChrismawan ArdiantoLong Chiau MingHooi Leng Ser DNA methylation is an epigenetic mark involving the addition of a methyl group to DNA, particularly at cytosine residues. This methylation plays an important role in regulating gene expression through direct gene repression or through the control of other epigenetic modifications such as histone modification or chromatin remodeling. DNA methylation is catalyzed by de novo and maintenance DNMT methyltransferase type enzymes and requires the transfer of a methyl group to cytosine to transform it into 5-methyl-cytosine. Currently, several investigations have highlighted the involvement of aberrant DNA methylation with certain tumors. Indeed, the methylation of antioncogenes and/or the demethylation of oncogenes are the major alterations that are strongly linked to human cancers. DNMTs play a central role in the epigenetic regulation of the human genome, both in normal and pathological processes. Recent discoveries on the differentiated roles of DNMTs in DNA methylation, and their implication in various cancers, open the way to new therapeutic approaches targeting these enzymes to treat epigenetic diseases. It is essential to continue exploring the roles of DNMTs to better understand their implication in tumorigenesis mechanisms and to develop more effective treatment strategies. https://journals.hh-publisher.com/index.php/pmmb/article/view/1102 |
| spellingShingle | Nasreddine El Omari Saad Bakrim Mohamed Bakha Abdelaali Balahbib Abdelhakim Bouyahya Chrismawan Ardianto Long Chiau Ming Hooi Leng Ser DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer Progress in Microbes and Molecular Biology |
| title | DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer |
| title_full | DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer |
| title_fullStr | DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer |
| title_full_unstemmed | DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer |
| title_short | DNA Methylation: Its Role and Interaction with Epigenetic Modifications in Cancer |
| title_sort | dna methylation its role and interaction with epigenetic modifications in cancer |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/1102 |
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