Mechanisms of pyroptosis in modulating osteoblast function under simulated microgravity

Mechanisms of pyroptosis in modulating osteoblast function under simulated microgravity

Abstract Background Bone mass loss resulting from mechanical unloading in a microgravity environment constitutes a primary impediment to the advancement of space exploration for astronauts. However, the underlying mechanism remains unclear. In this study, we primarily investigated the impact of pyro...

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Bibliographic Details
Main Authors: Min Wang, Jindong Xue, Songsong Liu, Congncong Xu, Zhen Cao, Haoyang Yu, Xiaojuan Nong, Kexin Huang, Shuling Hu, Yong Guo, Biao Han
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Musculoskeletal Disorders
Subjects:
Simulated microgravity
MC3T3-E1cells
Pyroptosis
NLRP3-casepase-1axis
Online Access:https://doi.org/10.1186/s12891-025-08629-5
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