PIWIL2/PDK1 Axis Promotes the Progression of Cervical Epithelial Lesions via Metabolic Reprogramming to Maintain Tumor‐Initiating Cell Stemness

PIWIL2/PDK1 Axis Promotes the Progression of Cervical Epithelial Lesions via Metabolic Reprogramming to Maintain Tumor‐Initiating Cell Stemness

Abstract When PIWIL2 expression is restored via heterogeneous integration of human papillomavirus, cellular reprogramming is initiated to form tumor‐initiating cells (TICs), which triggers cervical squamous intraepithelial lesions (SIL). TIC stemness is critical for the prognosis of SIL. However, th...

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Bibliographic Details
Main Authors: Yuebo Li, Wenhui Wang, Dongkui Xu, Haiyan Liang, Huan Yu, Ying Zhou, Jing Liang, Heming Sun, Xiaodie Liu, Ming Xue, Bin Ling, Dingqing Feng
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:Advanced Science
Subjects:
cervical lesion
pyruvate dehydrogenase kinase 1
stemness
tumor‐initiating cells
Online Access:https://doi.org/10.1002/advs.202410756
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