The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis
Purpose. To evaluate the diagnostic accuracy of retinal ganglion cell (RGC) counts as estimated by combining data from standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT). Methods. Healthy individuals and glaucoma patients were included in this cross-sectiona...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/2724312 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555981907689472 |
|---|---|
| author | Bruno L. B. Esporcatte Andrea C. Kara-José Luiz Alberto S. Melo Luciano M. Pinto Ivan M. Tavares |
| author_facet | Bruno L. B. Esporcatte Andrea C. Kara-José Luiz Alberto S. Melo Luciano M. Pinto Ivan M. Tavares |
| author_sort | Bruno L. B. Esporcatte |
| collection | DOAJ |
| description | Purpose. To evaluate the diagnostic accuracy of retinal ganglion cell (RGC) counts as estimated by combining data from standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT). Methods. Healthy individuals and glaucoma patients were included in this cross-sectional study. All eyes underwent 24-2 SITA SAP and structural imaging tests. RGC count estimates were obtained using a previously described algorithm, which combines estimates of RGC numbers from SAP sensitivity thresholds and SD-OCT retinal nerve fiber layer (RNFL) average thickness. Results. A total of 119 eyes were evaluated, including 75 eyes of 48 healthy individuals and 44 eyes of 29 glaucoma patients. RGC count estimates performed better than data derived from SD-OCT RNFL average thickness or SAP mean deviation alone (area under ROC curves: 0.98, 0.92, and 0.79; P<0.001) for discriminating healthy from glaucomatous eyes, even in a subgroup of eyes with mild disease (0.97, 0.88, and 0.75; P<0.001). There was a strong and significant correlation between estimates of RGC numbers derived from SAP and SD-OCT (R2=0.74; P<0.001). Conclusion. RGC count estimates obtained by combined structural and functional data showed excellent diagnostic accuracy for discriminating the healthy from the glaucomatous eyes and performed better than isolated structural and functional parameters. |
| format | Article |
| id | doaj-art-3ad06cd282ab421192b2a37bb5fe9a44 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-3ad06cd282ab421192b2a37bb5fe9a442025-02-03T05:46:39ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/27243122724312The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma DiagnosisBruno L. B. Esporcatte0Andrea C. Kara-José1Luiz Alberto S. Melo2Luciano M. Pinto3Ivan M. Tavares4Glaucoma Division, Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, BrazilGlaucoma Division, Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, BrazilGlaucoma Division, Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, BrazilGlaucoma Division, Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, BrazilGlaucoma Division, Department of Ophthalmology and Visual Sciences, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, BrazilPurpose. To evaluate the diagnostic accuracy of retinal ganglion cell (RGC) counts as estimated by combining data from standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT). Methods. Healthy individuals and glaucoma patients were included in this cross-sectional study. All eyes underwent 24-2 SITA SAP and structural imaging tests. RGC count estimates were obtained using a previously described algorithm, which combines estimates of RGC numbers from SAP sensitivity thresholds and SD-OCT retinal nerve fiber layer (RNFL) average thickness. Results. A total of 119 eyes were evaluated, including 75 eyes of 48 healthy individuals and 44 eyes of 29 glaucoma patients. RGC count estimates performed better than data derived from SD-OCT RNFL average thickness or SAP mean deviation alone (area under ROC curves: 0.98, 0.92, and 0.79; P<0.001) for discriminating healthy from glaucomatous eyes, even in a subgroup of eyes with mild disease (0.97, 0.88, and 0.75; P<0.001). There was a strong and significant correlation between estimates of RGC numbers derived from SAP and SD-OCT (R2=0.74; P<0.001). Conclusion. RGC count estimates obtained by combined structural and functional data showed excellent diagnostic accuracy for discriminating the healthy from the glaucomatous eyes and performed better than isolated structural and functional parameters.http://dx.doi.org/10.1155/2017/2724312 |
| spellingShingle | Bruno L. B. Esporcatte Andrea C. Kara-José Luiz Alberto S. Melo Luciano M. Pinto Ivan M. Tavares The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis Journal of Ophthalmology |
| title | The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis |
| title_full | The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis |
| title_fullStr | The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis |
| title_full_unstemmed | The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis |
| title_short | The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis |
| title_sort | estimates of retinal ganglion cell counts performed better than isolated structure and functional tests for glaucoma diagnosis |
| url | http://dx.doi.org/10.1155/2017/2724312 |
| work_keys_str_mv | AT brunolbesporcatte theestimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT andreackarajose theestimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT luizalbertosmelo theestimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT lucianompinto theestimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT ivanmtavares theestimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT brunolbesporcatte estimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT andreackarajose estimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT luizalbertosmelo estimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT lucianompinto estimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis AT ivanmtavares estimatesofretinalganglioncellcountsperformedbetterthanisolatedstructureandfunctionaltestsforglaucomadiagnosis |