Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types

Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types

Abstract Radioresistance is thought to be a major consequence of tumor milieu acidification resulting from the Warburg effect. Previously, using ogremorphin (OGM), a small molecule inhibitor of GPR68, an extracellular proton sensing receptor, we demonstrated that GPR68 is a key pro-survival pathway...

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Bibliographic Details
Main Authors: Leif R. Neitzel, Daniela T. Fuller, Jessica Cornell, Samantha Rea, Carolina de Aguiar Ferreira, Charles H. Williams, Charles C. Hong
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-88357-x
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