Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report
BackgroundCurrently, Listeria monocytogenes (LM) meningoencephalitis is rare in immunocompetent individuals, and its association with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is even more uncommon.Case presentationWe report a case of an immunocompetent adult female p...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1568219/full |
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| author | Jiahua Liang Gang Peng Yiyi Luo Jiayu Tang Jiayu Tang |
| author_facet | Jiahua Liang Gang Peng Yiyi Luo Jiayu Tang Jiayu Tang |
| author_sort | Jiahua Liang |
| collection | DOAJ |
| description | BackgroundCurrently, Listeria monocytogenes (LM) meningoencephalitis is rare in immunocompetent individuals, and its association with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is even more uncommon.Case presentationWe report a case of an immunocompetent adult female presenting with headache, fever, and vomiting, accompanied by hyponatremia and atypical splenial lesions of the corpus callosum on brain MRI. Both cerebrospinal fluid (CSF) metagenomic next-generation sequencing (mNGS) and culture confirmed LM infection, leading to a diagnosis of LM meningoencephalitis. The patient recovered completely after treatment with meropenem.ConclusionThis case highlights distinct clinical manifestations, laboratory findings, imaging features, and therapeutic responses in immunocompetent patients compared to immunocompromised populations. The atypical radiological presentation and favorable outcome underscore the importance of early pathogen identification via advanced diagnostics like mNGS. Our findings provide valuable insights into the heterogeneity of LM infections and emphasize the need for heightened clinical vigilance even in immunologically normal hosts. |
| format | Article |
| id | doaj-art-3acff757ca574f00a0818bf1e47f3237 |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-3acff757ca574f00a0818bf1e47f32372025-08-20T02:35:54ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-07-011210.3389/fmed.2025.15682191568219Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case reportJiahua Liang0Gang Peng1Yiyi Luo2Jiayu Tang3Jiayu Tang4The School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaThe School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaThe School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaThe School of Clinical Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Neurology, Brain Hospital of Hunan Province, Changsha, Hunan, ChinaBackgroundCurrently, Listeria monocytogenes (LM) meningoencephalitis is rare in immunocompetent individuals, and its association with mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is even more uncommon.Case presentationWe report a case of an immunocompetent adult female presenting with headache, fever, and vomiting, accompanied by hyponatremia and atypical splenial lesions of the corpus callosum on brain MRI. Both cerebrospinal fluid (CSF) metagenomic next-generation sequencing (mNGS) and culture confirmed LM infection, leading to a diagnosis of LM meningoencephalitis. The patient recovered completely after treatment with meropenem.ConclusionThis case highlights distinct clinical manifestations, laboratory findings, imaging features, and therapeutic responses in immunocompetent patients compared to immunocompromised populations. The atypical radiological presentation and favorable outcome underscore the importance of early pathogen identification via advanced diagnostics like mNGS. Our findings provide valuable insights into the heterogeneity of LM infections and emphasize the need for heightened clinical vigilance even in immunologically normal hosts.https://www.frontiersin.org/articles/10.3389/fmed.2025.1568219/fullListeria monocytogenesmeningoencephalitisMERSadult patients with normal immunitycase report |
| spellingShingle | Jiahua Liang Gang Peng Yiyi Luo Jiayu Tang Jiayu Tang Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report Frontiers in Medicine Listeria monocytogenes meningoencephalitis MERS adult patients with normal immunity case report |
| title | Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report |
| title_full | Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report |
| title_fullStr | Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report |
| title_full_unstemmed | Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report |
| title_short | Mild encephalitis/encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis: a case report |
| title_sort | mild encephalitis encephalopathy with reversible corpus callosum lesion associated with listeria infection with meningoencephalitis a case report |
| topic | Listeria monocytogenes meningoencephalitis MERS adult patients with normal immunity case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1568219/full |
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