Review of Atypical Organometallic Compounds as Antimalarial Drugs
Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2020/9414093 |
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| author | Samuel K. Kwofie Emmanuel Broni Bismark Dankwa Kweku S. Enninful Joshua Teye Cedar R. Davidson Josephine B. Nimely J. Chioma Orizu Prakasha Kempaiah Brijesh Rathi Whelton A. Miller |
| author_facet | Samuel K. Kwofie Emmanuel Broni Bismark Dankwa Kweku S. Enninful Joshua Teye Cedar R. Davidson Josephine B. Nimely J. Chioma Orizu Prakasha Kempaiah Brijesh Rathi Whelton A. Miller |
| author_sort | Samuel K. Kwofie |
| collection | DOAJ |
| description | Organometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested. |
| format | Article |
| id | doaj-art-3acc6d48ddd1469aa44c4df4e07f40d9 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-3acc6d48ddd1469aa44c4df4e07f40d92025-02-03T01:26:57ZengWileyJournal of Chemistry2090-90632090-90712020-01-01202010.1155/2020/94140939414093Review of Atypical Organometallic Compounds as Antimalarial DrugsSamuel K. Kwofie0Emmanuel Broni1Bismark Dankwa2Kweku S. Enninful3Joshua Teye4Cedar R. Davidson5Josephine B. Nimely6J. Chioma Orizu7Prakasha Kempaiah8Brijesh Rathi9Whelton A. Miller10Department of Biomedical Engineering, School of Engineering Sciences, College of Basic and Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, GhanaDepartment of Biomedical Engineering, School of Engineering Sciences, College of Basic and Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, GhanaDepartment of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra, GhanaDepartment of Parasitology, Noguchi Memorial Institute for Medical Research (NMIMR), College of Health Sciences (CHS), University of Ghana, Legon, Accra, GhanaDepartment of Biomedical Engineering, School of Engineering Sciences, College of Basic and Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, GhanaDepartment of Biology, Lincoln University, Chester County, PA 19352, USADepartment of Biology, Lincoln University, Chester County, PA 19352, USADepartment of Chemistry, Physics & Engineering, Lincoln University, Chester County, PA 19352, USADepartment of Medicine, Loyola University Chicago, Loyola University Medical Center, Maywood, IL 60153, USADepartment of Medicine, Loyola University Chicago, Loyola University Medical Center, Maywood, IL 60153, USADepartment of Biomedical Engineering, School of Engineering Sciences, College of Basic and Applied Sciences, University of Ghana, PMB LG 77, Legon, Accra, GhanaOrganometallic compounds are molecules that contain at least one metal-carbon bond. Due to resistance of the Plasmodium parasite to traditional organic antimalarials, the use of organometallic compounds has become widely adopted in antimalarial drug discovery. Ferroquine, which was developed due to the emergence of chloroquine resistance, is currently the most advanced organometallic antimalarial drug and has paved the way for the development of new organometallic antimalarials. In this review, a general overview of organometallic antimalarial compounds and their antimalarial activity in comparison to purely organic antimalarials are presented. Furthermore, recent developments in the field are discussed, and future applications of this emerging class of therapeutics in antimalarial drug discovery are suggested.http://dx.doi.org/10.1155/2020/9414093 |
| spellingShingle | Samuel K. Kwofie Emmanuel Broni Bismark Dankwa Kweku S. Enninful Joshua Teye Cedar R. Davidson Josephine B. Nimely J. Chioma Orizu Prakasha Kempaiah Brijesh Rathi Whelton A. Miller Review of Atypical Organometallic Compounds as Antimalarial Drugs Journal of Chemistry |
| title | Review of Atypical Organometallic Compounds as Antimalarial Drugs |
| title_full | Review of Atypical Organometallic Compounds as Antimalarial Drugs |
| title_fullStr | Review of Atypical Organometallic Compounds as Antimalarial Drugs |
| title_full_unstemmed | Review of Atypical Organometallic Compounds as Antimalarial Drugs |
| title_short | Review of Atypical Organometallic Compounds as Antimalarial Drugs |
| title_sort | review of atypical organometallic compounds as antimalarial drugs |
| url | http://dx.doi.org/10.1155/2020/9414093 |
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