Lysosomal damage promotes autophagy-based unconventional secretion of the Parkinson’s disease protein PARK7

Lysosomal damage promotes autophagy-based unconventional secretion of the Parkinson’s disease protein PARK7

Objective: PARK7/DJ-1 is a multifunctional protein and redox sensor essential for cellular survival and oxidative stress defense. PARK7 secretion is linked to pathophysiologies, including neurodegenerative diseases, cancer and inflammation. This study investigates the mechanisms of PARK7 secretion i...

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Bibliographic Details
Main Authors: Biplab Kumar Dash, Yasuomi Urano, Noriko Noguchi
Format: Article
Language:English
Published: Bioscientifica 2024-12-01
Series:Redox Experimental Medicine
Subjects:
park7/dj-1
unconventional secretion
lysophagy
secretory autophagosome
neurodegenerative diseases
Online Access:https://rem.bioscientifica.com/view/journals/rem/2024/1/REM-24-0014.xml
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