Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata)
The objective of this study is to evaluate the effects of incorporating bioactive peptides (BPs) from salmon processing by-product into the diets of gilthead seabream (Sparus aurata), assessing key parameters including growth performance, blood biochemistry, immune-related gene expression, and gut h...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | Aquaculture Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352513425001267 |
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| author | Elisa Benini Eliana Musmeci Serena Busti Elena Biagi Sara Ciulli Enrico Volpe Francesca Errani Åge Oterhals Odd Helge Romarheim Tone Aspevik Francesco Dondi Giulio Zanaroli Pier Paolo Gatta Alessio Bonaldo Luca Parma |
| author_facet | Elisa Benini Eliana Musmeci Serena Busti Elena Biagi Sara Ciulli Enrico Volpe Francesca Errani Åge Oterhals Odd Helge Romarheim Tone Aspevik Francesco Dondi Giulio Zanaroli Pier Paolo Gatta Alessio Bonaldo Luca Parma |
| author_sort | Elisa Benini |
| collection | DOAJ |
| description | The objective of this study is to evaluate the effects of incorporating bioactive peptides (BPs) from salmon processing by-product into the diets of gilthead seabream (Sparus aurata), assessing key parameters including growth performance, blood biochemistry, immune-related gene expression, and gut health. Furthermore, the investigation explores potential advantages within the climate change context, providing a comprehensive understanding of the diverse implications associated with this dietary approach. Three distinct diets with varying BP levels (0 % [BP0], 5 % [BP5], 10 % [BP10]) as substitutions for fish meal (FM) were administered to triplicate fish groups over a 58-day trial period. Following the trial, fish were exposed to suboptimal environmental conditions (high water temperature, low oxygen) for 7 days. Analysis of growth and somatometric parameters revealed no significant differences among fish fed the three experimental diets. Additionally, the highest dosage of BP (BP10) induced a significant increase of bacterial α-diversity, suggesting potential benefits. Moreover, the expression of immune genes suggested a generally stable immune response in fish before (T1) and after (T2) challenging environmental conditions. However, the lower expression of ferritin and C3 hints toward a possible alteration of immune response in fish fed BP10 after environmental stress Additionally, challenging environmental conditions combined with high dietary inclusion of BP (10 %) triggered a physiological stress response, evidenced by elevated glucose, creatinine and uric acid levels, potentially indicating impairment of kidney function and reduced fish fitness. Furthermore, when singularly correlating gut microbiome and plasma analyses, data showed that higher presence of Stenotrophomonas and Acinetobacter families were positively related to higher lactate hematic concentration, suggesting a physiological distress caused by the inclusion of 10 % of BP in seabream diet exacerbated by adverse environmental conditions. Overall, while BP inclusion offers a sustainable alternative protein source, incorporating more than 5 % in the diet might compromise fish health under challenging environmental conditions. |
| format | Article |
| id | doaj-art-3ac12f1a9cc14510b46e82d2d9abd9ff |
| institution | OA Journals |
| issn | 2352-5134 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Aquaculture Reports |
| spelling | doaj-art-3ac12f1a9cc14510b46e82d2d9abd9ff2025-08-20T02:05:19ZengElsevierAquaculture Reports2352-51342025-07-014210274010.1016/j.aqrep.2025.102740Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata)Elisa Benini0Eliana Musmeci1Serena Busti2Elena Biagi3Sara Ciulli4Enrico Volpe5Francesca Errani6Åge Oterhals7Odd Helge Romarheim8Tone Aspevik9Francesco Dondi10Giulio Zanaroli11Pier Paolo Gatta12Alessio Bonaldo13Luca Parma14Department of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, Italy; Correspondence to: Department of Veterinary Medical Sciences, University of Bologna, Viale Vespucci 2, Cesenatico, FC 47042, Italy.Department of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna Via Terracini, 28 - Via del Lazzaretto, 15/5, Bologna 40131, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyDepartment of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna Via Terracini, 28 - Via del Lazzaretto, 15/5, Bologna 40131, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyNofima, Norwegian Institute of Food Fisheries and Aquaculture Research, Kjerreidviken 16, Bergen, Fyllingsdalen 5141, NorwayBioMar Norge, Bolstadsvei 24, Myre 8430, NorwayNofima, Norwegian Institute of Food Fisheries and Aquaculture Research, Kjerreidviken 16, Bergen, Fyllingsdalen 5141, NorwayDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyDepartment of Civil, Chemical, Environmental and Materials Engineering (DICAM), University of Bologna Via Terracini, 28 - Via del Lazzaretto, 15/5, Bologna 40131, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyDepartment of Veterinary Medical Sciences (DIMEVET), University of Bologna, Via Tolara di Sopra 50, Bologna, Ozzano Emilia 40064, ItalyThe objective of this study is to evaluate the effects of incorporating bioactive peptides (BPs) from salmon processing by-product into the diets of gilthead seabream (Sparus aurata), assessing key parameters including growth performance, blood biochemistry, immune-related gene expression, and gut health. Furthermore, the investigation explores potential advantages within the climate change context, providing a comprehensive understanding of the diverse implications associated with this dietary approach. Three distinct diets with varying BP levels (0 % [BP0], 5 % [BP5], 10 % [BP10]) as substitutions for fish meal (FM) were administered to triplicate fish groups over a 58-day trial period. Following the trial, fish were exposed to suboptimal environmental conditions (high water temperature, low oxygen) for 7 days. Analysis of growth and somatometric parameters revealed no significant differences among fish fed the three experimental diets. Additionally, the highest dosage of BP (BP10) induced a significant increase of bacterial α-diversity, suggesting potential benefits. Moreover, the expression of immune genes suggested a generally stable immune response in fish before (T1) and after (T2) challenging environmental conditions. However, the lower expression of ferritin and C3 hints toward a possible alteration of immune response in fish fed BP10 after environmental stress Additionally, challenging environmental conditions combined with high dietary inclusion of BP (10 %) triggered a physiological stress response, evidenced by elevated glucose, creatinine and uric acid levels, potentially indicating impairment of kidney function and reduced fish fitness. Furthermore, when singularly correlating gut microbiome and plasma analyses, data showed that higher presence of Stenotrophomonas and Acinetobacter families were positively related to higher lactate hematic concentration, suggesting a physiological distress caused by the inclusion of 10 % of BP in seabream diet exacerbated by adverse environmental conditions. Overall, while BP inclusion offers a sustainable alternative protein source, incorporating more than 5 % in the diet might compromise fish health under challenging environmental conditions.http://www.sciencedirect.com/science/article/pii/S2352513425001267Bioactive peptidesGilthead seabreamGut microbiomeClimate change contextSustainable protein source |
| spellingShingle | Elisa Benini Eliana Musmeci Serena Busti Elena Biagi Sara Ciulli Enrico Volpe Francesca Errani Åge Oterhals Odd Helge Romarheim Tone Aspevik Francesco Dondi Giulio Zanaroli Pier Paolo Gatta Alessio Bonaldo Luca Parma Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata) Aquaculture Reports Bioactive peptides Gilthead seabream Gut microbiome Climate change context Sustainable protein source |
| title | Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata) |
| title_full | Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata) |
| title_fullStr | Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata) |
| title_full_unstemmed | Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata) |
| title_short | Bioactive peptides from salmon aquaculture processing by-product affect growth performance, plasma biochemistry, gut health, and stress resistance of gilthead seabream (Sparus aurata) |
| title_sort | bioactive peptides from salmon aquaculture processing by product affect growth performance plasma biochemistry gut health and stress resistance of gilthead seabream sparus aurata |
| topic | Bioactive peptides Gilthead seabream Gut microbiome Climate change context Sustainable protein source |
| url | http://www.sciencedirect.com/science/article/pii/S2352513425001267 |
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