Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment
Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging the unique advantages of nanotechnology to enhance the effectiveness and specificity of cancer treatments. These vaccines utilize nanoscale carriers to deliver tumor-associated antigens and i...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Nanomaterials |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-4991/15/2/122 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832587793446993920 |
|---|---|
| author | Chao Chen Yue Xu Hui Meng Hongyi Bao Yong Hu Chunjian Li Donglin Xia |
| author_facet | Chao Chen Yue Xu Hui Meng Hongyi Bao Yong Hu Chunjian Li Donglin Xia |
| author_sort | Chao Chen |
| collection | DOAJ |
| description | Nano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging the unique advantages of nanotechnology to enhance the effectiveness and specificity of cancer treatments. These vaccines utilize nanoscale carriers to deliver tumor-associated antigens and immunostimulatory adjuvants, facilitating targeted immune activation and promoting robust antitumor responses. By improving antigen presentation and localizing immune activation within the tumor microenvironment, nano-oncologic vaccines can significantly increase the efficacy of cancer immunotherapy, particularly when combined with other treatment modalities. This review highlights the mechanisms through which nano-oncologic vaccines operate, their potential to overcome existing limitations in cancer treatment, and ongoing advancements in design. Additionally, it discusses the targeted delivery approach, such as EPR effects, pH response, ultrasonic response, and magnetic response. The combination therapy effects with photothermal therapy, radiotherapy, or immune checkpoint inhibitors are also discussed. Overall, nano-oncologic vaccines hold great promise for changing the landscape of cancer treatment and advancing personalized medicine, paving the way for more effective therapeutic strategies tailored to individual patient needs. |
| format | Article |
| id | doaj-art-3ac089840c044fc2b576d81a8a3c6571 |
| institution | Kabale University |
| issn | 2079-4991 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj-art-3ac089840c044fc2b576d81a8a3c65712025-01-24T13:44:13ZengMDPI AGNanomaterials2079-49912025-01-0115212210.3390/nano15020122Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer TreatmentChao Chen0Yue Xu1Hui Meng2Hongyi Bao3Yong Hu4Chunjian Li5Donglin Xia6Institute for Applied Research in Public Health, School of Public Health, Nantong University, Nantong 226019, ChinaInstitute for Applied Research in Public Health, School of Public Health, Nantong University, Nantong 226019, ChinaInstitute for Applied Research in Public Health, School of Public Health, Nantong University, Nantong 226019, ChinaSchool of Medicine, Nantong University, Nantong 226019, ChinaNanjing University (Suzhou) High-Tech Institute, Renai Road 150, Suzhou Industrial Park, Suzhou 215123, ChinaCenter of Forecasting and Analysis, Nantong University, Nantong 226019, ChinaInstitute for Applied Research in Public Health, School of Public Health, Nantong University, Nantong 226019, ChinaNano-oncologic vaccines represent a groundbreaking approach in the field of cancer immunotherapy, leveraging the unique advantages of nanotechnology to enhance the effectiveness and specificity of cancer treatments. These vaccines utilize nanoscale carriers to deliver tumor-associated antigens and immunostimulatory adjuvants, facilitating targeted immune activation and promoting robust antitumor responses. By improving antigen presentation and localizing immune activation within the tumor microenvironment, nano-oncologic vaccines can significantly increase the efficacy of cancer immunotherapy, particularly when combined with other treatment modalities. This review highlights the mechanisms through which nano-oncologic vaccines operate, their potential to overcome existing limitations in cancer treatment, and ongoing advancements in design. Additionally, it discusses the targeted delivery approach, such as EPR effects, pH response, ultrasonic response, and magnetic response. The combination therapy effects with photothermal therapy, radiotherapy, or immune checkpoint inhibitors are also discussed. Overall, nano-oncologic vaccines hold great promise for changing the landscape of cancer treatment and advancing personalized medicine, paving the way for more effective therapeutic strategies tailored to individual patient needs.https://www.mdpi.com/2079-4991/15/2/122nano-oncologic vaccinesconstructionimmunotherapytarget deliverycombination therapy |
| spellingShingle | Chao Chen Yue Xu Hui Meng Hongyi Bao Yong Hu Chunjian Li Donglin Xia Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment Nanomaterials nano-oncologic vaccines construction immunotherapy target delivery combination therapy |
| title | Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment |
| title_full | Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment |
| title_fullStr | Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment |
| title_full_unstemmed | Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment |
| title_short | Nano-Oncologic Vaccine for Boosting Cancer Immunotherapy: The Horizons in Cancer Treatment |
| title_sort | nano oncologic vaccine for boosting cancer immunotherapy the horizons in cancer treatment |
| topic | nano-oncologic vaccines construction immunotherapy target delivery combination therapy |
| url | https://www.mdpi.com/2079-4991/15/2/122 |
| work_keys_str_mv | AT chaochen nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment AT yuexu nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment AT huimeng nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment AT hongyibao nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment AT yonghu nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment AT chunjianli nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment AT donglinxia nanooncologicvaccineforboostingcancerimmunotherapythehorizonsincancertreatment |