Pace-maker f-channels of sinus node myocytеs as a new therapeutic target for heart rate reduction

Pace-maker f-channels of sinus node myocytеs as a new therapeutic target for heart rate reduction

Heart pace-maker activity is controlled by highly specialized sinus node (SN) myocytes. This control is linked to functional activity of f-channels providing Na+ and К+ If current. F-channels are activated by plasmatic membrane hyperpolarization in pace-maker cells, at diastolic values of membrane p...

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Bibliographic Details
Main Authors: E. I. Astashkin, M. G. Glezer
Format: Article
Language:Russian
Published: «SILICEA-POLIGRAF» LLC 1970-01-01
Series:Кардиоваскулярная терапия и профилактика
Subjects:
pace-maker activity
sinus node
f-channels
if current
ivabradine
heart rate
angina treatment
Online Access:https://cardiovascular.elpub.ru/jour/article/view/1606
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