Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia
Abstract Background Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension may impact the incident early-...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-025-07193-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585272260296704 |
|---|---|
| author | Meiling Ye Cailing Zhou Lu Li Lizhen Wang Meixian Zhang |
| author_facet | Meiling Ye Cailing Zhou Lu Li Lizhen Wang Meixian Zhang |
| author_sort | Meiling Ye |
| collection | DOAJ |
| description | Abstract Background Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension may impact the incident early-onset neonatal thrombocytopenia. Methods We included 538 neonates, comprising 318 and 220 neonates born to healthy mothers and those with pregnancy-induced hypertension. The minimum platelet count within 72 h of birth was recorded for these neonates. The incidence of early-onset thrombocytopenia in neonates in relation to maternal gestational hypertension, preeclampsia, and health status was evaluated. Logistic regression analysis was conducted to assess the relationship between maternal gestational hypertension and the risk of early-onset neonatal thrombocytopenia. Results The incidence of early-onset thrombocytopenia was significantly higher in neonates born to mothers with preeclampsia than in those born to mothers with gestational hypertension or healthy mothers. Significant differences were observed among the three groups (30.0% vs. 13.3% vs. 7.9%, p < 0.001). Maternal gestational hypertension (OR = 2.79, 95%CI 1.19–6.54) increased the risk of early-onset neonatal thrombocytopenia when compared to healthy mothers. Conclusions Maternal gestational hypertension increases the occurrence of early-onset neonatal thrombocytopenia. Therefore, we recommend conducting platelet count screening at the early stages of neonates of mothers with gestational hypertension. |
| format | Article |
| id | doaj-art-3ab9396dc2b84388a4cababae5ccc0cd |
| institution | Kabale University |
| issn | 1471-2393 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj-art-3ab9396dc2b84388a4cababae5ccc0cd2025-01-26T12:57:13ZengBMCBMC Pregnancy and Childbirth1471-23932025-01-012511910.1186/s12884-025-07193-zEffects of pregnancy-induced hypertension on early-onset neonatal thrombocytopeniaMeiling Ye0Cailing Zhou1Lu Li2Lizhen Wang3Meixian Zhang4Department of Neonatology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Enze Hospital, Taizhou Enze Medical Center (Group)Department of Neonatology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Enze Hospital, Taizhou Enze Medical Center (Group)Department of Neonatology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Enze Hospital, Taizhou Enze Medical Center (Group)Department of Neonatology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Enze Hospital, Taizhou Enze Medical Center (Group)Department of Neonatology, Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University, Enze Hospital, Taizhou Enze Medical Center (Group)Abstract Background Gestational hypertension and preeclampsia are potentially linked to similar pathophysiological processes. Maternal preeclampsia increases the occurrence of early-onset neonatal thrombocytopenia. We hypothesized that maternal gestational hypertension may impact the incident early-onset neonatal thrombocytopenia. Methods We included 538 neonates, comprising 318 and 220 neonates born to healthy mothers and those with pregnancy-induced hypertension. The minimum platelet count within 72 h of birth was recorded for these neonates. The incidence of early-onset thrombocytopenia in neonates in relation to maternal gestational hypertension, preeclampsia, and health status was evaluated. Logistic regression analysis was conducted to assess the relationship between maternal gestational hypertension and the risk of early-onset neonatal thrombocytopenia. Results The incidence of early-onset thrombocytopenia was significantly higher in neonates born to mothers with preeclampsia than in those born to mothers with gestational hypertension or healthy mothers. Significant differences were observed among the three groups (30.0% vs. 13.3% vs. 7.9%, p < 0.001). Maternal gestational hypertension (OR = 2.79, 95%CI 1.19–6.54) increased the risk of early-onset neonatal thrombocytopenia when compared to healthy mothers. Conclusions Maternal gestational hypertension increases the occurrence of early-onset neonatal thrombocytopenia. Therefore, we recommend conducting platelet count screening at the early stages of neonates of mothers with gestational hypertension.https://doi.org/10.1186/s12884-025-07193-zGestational hypertensionPreeclampsiaNeonatal thrombocytopeniaPlatelet count screening |
| spellingShingle | Meiling Ye Cailing Zhou Lu Li Lizhen Wang Meixian Zhang Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia BMC Pregnancy and Childbirth Gestational hypertension Preeclampsia Neonatal thrombocytopenia Platelet count screening |
| title | Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia |
| title_full | Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia |
| title_fullStr | Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia |
| title_full_unstemmed | Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia |
| title_short | Effects of pregnancy-induced hypertension on early-onset neonatal thrombocytopenia |
| title_sort | effects of pregnancy induced hypertension on early onset neonatal thrombocytopenia |
| topic | Gestational hypertension Preeclampsia Neonatal thrombocytopenia Platelet count screening |
| url | https://doi.org/10.1186/s12884-025-07193-z |
| work_keys_str_mv | AT meilingye effectsofpregnancyinducedhypertensiononearlyonsetneonatalthrombocytopenia AT cailingzhou effectsofpregnancyinducedhypertensiononearlyonsetneonatalthrombocytopenia AT luli effectsofpregnancyinducedhypertensiononearlyonsetneonatalthrombocytopenia AT lizhenwang effectsofpregnancyinducedhypertensiononearlyonsetneonatalthrombocytopenia AT meixianzhang effectsofpregnancyinducedhypertensiononearlyonsetneonatalthrombocytopenia |