A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs

A Novel Approach for In Vitro Testing and Hazard Evaluation of Nanoformulated RyR2-Targeting siRNA Drugs Using Human PBMCs

Nucleic acid (NA)-based drugs are promising therapeutics agents. Beyond efficacy, addressing safety concerns—particularly those specific to this class of drugs—is crucial. Here, we propose an in vitro approach to screen for potential adverse off-target effects of NA-based drugs. Human peripheral blo...

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Bibliographic Details
Main Authors: Valeria Bettinsoli, Gloria Melzi, Angelica Crea, Lorenzo Degli Esposti, Michele Iafisco, Daniele Catalucci, Paolo Ciana, Emanuela Corsini
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Life
Subjects:
new approach methodologies
peripheral blood mononuclear cells
nucleic acid drugs
immunotoxicology
toxicity pathways
RyR2
Online Access:https://www.mdpi.com/2075-1729/15/1/95
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